Dexamethasone sodium phosphate EP Impurity G CAS 37927-01-8
| CAS No. | 37927-01-8 |
| Molecular Formula | C21H27FO5 |
| Molecular Weight | 378.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dexamethasone sodium phosphate EP Impurity G (C21H27FO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Dexamethasone sodium phosphate EP Impurity G (CAS 37927-01-8), a pharmacopoeial impurity reference standard (molecular formula C21H27FO5, MW 378.43 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H27FO5 |
| Molecular Weight | 378.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 43 (CAS CATO-C4X-116543)
- Dexamethasone Isonicotinate EP Impurity C (CAS 426-15-3)
- Dexamethasone EP Impurity F (CAS 382-67-2)
- Dexamethasone Desfluoro 11-Epimer (CAS 78761-59-8)
- Dexamethasone Oxetanone (CAS 4089-36-5)
- Dexamethasone Impurity 104 (CAS 62800-49-1)
- Dexamethasone Impurity 120 (CAS CATO-C4X-1165120)
- Dexamethasone Impurity 23 (CAS 59860-99-0)
Recommended Standards
- Palbociclib Impurity 86 (CAS 2363172-64-7)
- Betamethasone Impurity 29 (CAS 37926-75-3)
- N-(2-(Benzo[a]phenazin-5-ylamino)phenyl)acetamide (CAS 61316-66-3)
- Isoflupredone (CAS 338-95-4)
- Cefpodoxime Impurity 32 (CAS 24701-69-7)
- Tiamulin EP Impurity T Fumarate (CAS CATO-C4X-22105)
- Lornoxicam Impurity 33 (CAS 941239-79-8)
- 5-Chloro-3H-spiro[benzofuran-2,4'-piperidine] (CAS 71916-97-7)
- N-[(1-Aminocyclopentyl)methyl]acetamide (CAS 904815-32-3)
- 5-Cyclopropyl-3-iodo-1H-indazole (CAS 1360946-18-4)
- 2-(Benzyloxy)-5-nitrophenol (CAS 2242-35-5)
- [1,2,4]Triazolo[4,3-a]pyrimidin-6-yl(pyrrolidin-1-yl)methanone (CAS 1779132-22-7)
- 5-Amino-1H-benzo[d][1,3]oxazin-2(4H)-one (CAS 1002129-69-2)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com