Doxazosin EP Impurity F CAS 23680-84-4
| CAS No. | 23680-84-4 |
| Molecular Formula | C10H10ClN3O2 |
| Molecular Weight | 239.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Doxazosin EP Impurity F (CAS 23680-84-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H10ClN3O2 and a molecular weight of 239.66 g/mol.
The molecular framework of Doxazosin EP Impurity F (C10H10ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H10ClN3O2 |
| Molecular Weight | 239.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Doxazosin Standards
- Doxazosin EP Impurity D (CAS 28888-44-0)
- Doxazosin Impurity 19 (CAS CATO-C4X-162319)
- Doxazosin EP Impurity E (CAS 27631-29-4)
- Doxazosin Impurity 15 (CAS 60547-96-8)
- Doxazosin Impurity 2 (CAS 4739-94-0)
- Doxazosin Impurity 20 (CAS CATO-C4X-162320)
- Doxazosin Impurity 10 (CAS 3663-79-4)
- Doxazosin EP Impurity G (CAS 60547-97-9)
Recommended Standards
- Rivaroxaban Impurity 94 (CAS 148857-44-7)
- Cloxacillin Impurity 26 (CAS CATO-C4X-159726)
- Rivaroxaban Impurity 49 (CAS 148857-42-5)
- Tolvaptan Impurity 107 (CAS 2735310-65-1)
- Arotinolol Impurity 39 (CAS CATO-C4X-185439)
- Metformin Impurity 15 (CAS 786681-13-8)
- Atropine Impruity 2 (CAS CATO-C4X-14892)
- 1-Cyclopropyl-5-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 2384171-57-5)
- (3-Fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)boronic acid (CAS 1704064-09-4)
- Cetrimide (CAS 1119-97-7)
- 1-(TRiphenylmethyl)imidazole-4-carbonitrile (CAS 340179-96-6)
- Salicylic Acid Impurity 21 (CAS CATO-C4X-190221)
- N-Methyl-3-chlorophenethylamine (CAS 52516-20-8)
- HIV (gp120) Antigenic Peptide (H-2982.0500) (CAS 198636-94-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com