Doxazosin Impurity 2 CAS 4739-94-0
| CAS No. | 4739-94-0 |
| Molecular Formula | C11H12O4 |
| Molecular Weight | 208.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Doxazosin Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Doxazosin Impurity 2 (CAS 4739-94-0), a pharmacopoeial impurity reference standard (molecular formula C11H12O4, MW 208.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Doxazosin Impurity 2 (C11H12O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H12O4 |
| Molecular Weight | 208.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Doxazosin Standards
- Doxazosin Impurity 15 (CAS 60547-96-8)
- Doxazosin Impurity 19 (CAS CATO-C4X-162319)
- Doxazosin EP Impurity D (CAS 28888-44-0)
- Doxazosin Impurity 10 (CAS 3663-79-4)
- Doxazosin EP Impurity A (CAS 3663-80-7)
- Doxazosin EP Impurity F (CAS 23680-84-4)
- Doxazosin EP Impurity E (CAS 27631-29-4)
- Doxazosin Impurity 20 (CAS CATO-C4X-162320)
Recommended Standards
- Dimethyl bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate (CAS 947-57-9)
- Ethyl (4-formylphenoxy)acetate (CAS 51264-69-8)
- Dimethyl 4-methylphthalate (CAS 20116-65-8)
- Ethyl (S)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate (CAS 882980-86-1)
- Zoledronic Acid Impurity 2（Zoledronic Acid EP Impurity B） (CAS 1627731-61-6)
- Carvedilol impurity 10 (CAS 1276477-91-8)
- Tryptophan EP Impurity H (CAS 6052-68-2)
- (R)-3-(Phenylsulfonyl)pyrrolidine (CAS 1268521-39-6)
- (S)-1-(3-(trifluoromethoxy)phenyl)pentan-1-amine (CAS 1213828-50-2)
- 2-(4-Bromophenyl)-1H-indole-3-carbaldehyde (CAS 54031-95-7)
- 4-Bromo-3-cyclopropylbenzoic acid (CAS 2384580-34-9)
- tert-Butyl (2-amino-5-fluorophenyl)carbamate (CAS 362670-07-3)
- N-(4-(benzyloxy)phenyl)cyclobutanecarboxamide (CAS 925605-98-7)
- Neuropeptide FF (CAS 99566-27-5)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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