Doxazosin Impurity 10 CAS 3663-79-4
| CAS No. | 3663-79-4 |
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Doxazosin Impurity 10.
Doxazosin Impurity 10 (CAS 3663-79-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H10O4 and a molecular weight of 194.18 g/mol.
The molecular framework of Doxazosin Impurity 10 (C10H10O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Doxazosin Standards
- Doxazosin EP Impurity A (CAS 3663-80-7)
- Doxazosin Impurity 2 (CAS 4739-94-0)
- Doxazosin Impurity 15 (CAS 60547-96-8)
- Doxazosin Impurity 19 (CAS CATO-C4X-162319)
- Doxazosin EP Impurity D (CAS 28888-44-0)
- Doxazosin EP Impurity F (CAS 23680-84-4)
- Doxazosin EP Impurity E (CAS 27631-29-4)
- Doxazosin Impurity 20 (CAS CATO-C4X-162320)
Recommended Standards
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- Desloratadine Impurity 38 (CAS 7541-16-4)
- Efavirenz Impurity 13 (CAS 927812-33-7)
- Eletriptan Impurity 1 (CAS 6163-58-2)
- 2-(4-Aminophenyl)-N,N,5-trimethyloxazole-4-carboxamide (CAS 1334487-96-5)
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- 5-Bromo-6-fluoro-1H-indazole-3-carboxylic acid (CAS 1360928-47-7)
- 2-Chloro-4-methylthiophen-3-amine hydrochloride (CAS 848252-38-0)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
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