[2-Chloro-5-hydroxy-4-(trifluoromethoxy)phenyl]boronic acid CAS 2377606-01-2
| CAS No. | 2377606-01-2 |
| Molecular Formula | C7H5BClF3O4 |
| Molecular Weight | 256.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of [2-Chloro-5-hydroxy-4-(trifluoromethoxy)phenyl]boronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies [2-Chloro-5-hydroxy-4-(trifluoromethoxy)phenyl]boronic acid (CAS 2377606-01-2), a certified reference material (molecular formula C7H5BClF3O4, MW 256.37 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, [2-Chloro-5-hydroxy-4-(trifluoromethoxy)phenyl]boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 256.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), [2-Chloro-5-hydroxy-4-(trifluoromethoxy)phenyl]boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5BClF3O4 |
| Molecular Weight | 256.37 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
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