3-(t-Butyldimethylsilyloxy)-4-fluorophenylboronic acid CAS 2377608-43-8
| CAS No. | 2377608-43-8 |
| Molecular Formula | C12H20BFO3Si |
| Molecular Weight | 270.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(t-Butyldimethylsilyloxy)-4-fluorophenylboronic acid (CAS 2377608-43-8), molecular formula C12H20BFO3Si and molecular weight 270.18 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 3-(t-Butyldimethylsilyloxy)-4-fluorophenylboronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(t-Butyldimethylsilyloxy)-4-fluorophenylboronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H20BFO3Si |
| Molecular Weight | 270.18 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
Related t Standards
- 3-(t-Butyldimethylsilyloxy)-2-fluorophenylboronic acid (CAS 2096331-47-2)
- 1-(tert-Butyldimethylsilyloxy)-1-(2-trimethylsilyl)ethynylcyclopropane (CAS 1246816-70-5)
- 1-(tert-Butyldimethylsilyloxy)-1-(2'-trimethylsilyl)ethynyl-cyclopropane-d4 (CAS 1246820-34-7)
- 1-(2-(tert-Butyldimethylsilyloxy)propyl)-1H-imidazole-2-carbaldehyde (CAS 1820741-32-9)
- 1076199-66-0 3-(tert-Butyldimethylsilyloxy)-5-(1-methylamino)-5-oxopentanoic Acid 3-[(1,1-Dimethylethyl)dimethylsilyloxy]-5-(1-methylamino)-5-oxopentanoic Acid (CAS 1076199-66-0)
- 8-(tert-Butyldimethylsilyloxy)-1-octanol (CAS 91898-32-7)
- 4-(tert-Butyldimethylsilyloxy)methyl-3-methylphenylboronic acid (CAS 2377608-40-5)
- 5-(t-Butyldimethylsilyloxy)-2-methoxyphenylboronic acid (CAS 1150114-54-7)
Recommended Standards
- 4-(((Trifluoromethyl)sulfonyl)oxy)benzoic acid (CAS 32578-34-0)
- 2,3,5,6-Tetrafluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 53987-59-0)
- 5-Ethoxy-5-oxo-4-(2,2,2-trifluoroacetamido)pentanoic acid (CAS 88494-57-9)
- {4-[(tert-Butyldimethylsilyl)oxy]-2-fluorophenyl}boronic acid (CAS 2377608-27-8)
- Ethyl 3-(2-nitrophenyl)acrylate (CAS 2437-05-0)
- 2-({[(tert-butoxy)carbonyl]amino}methyl)pentanoic acid (CAS 1490249-28-9)
- 4-(2-Biphenyl)-2-methyl-1-butene (CAS 951890-11-2)
- N-(1-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(furan-2-yl)-1H-pyrazol-5-yl)-4-methoxybenzenesulfonamide (CAS 1170240-44-4)
- 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (CAS 1936529-65-5)
- 2-Amino-3-(3,5-dimethyl-1h-pyrazol-1-yl)-2-methylpropanamide (CAS 1249565-69-2)
- (3-Aminopyrrolidin-1-yl)(3-fluoro-4-methylphenyl)methanone hydrochloride (CAS 1605157-02-5)
- 2-amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol hydrochloride (CAS 62064-75-9)
- 5-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]pyridazine-3,6(5H)-dione (CAS 338418-81-8)
- Cycloaspeptide A (CAS 109171-13-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com