Abemaciclib Impurity 55 CAS 2379819-71-1
| CAS No. | 2379819-71-1 |
| Molecular Formula | C18H36N4Si2 |
| Molecular Weight | 364.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Abemaciclib Impurity 55 (CAS 2379819-71-1, C18H36N4Si2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Abemaciclib Impurity 55 (C18H36N4Si2) contains a nitrile group. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 364.68 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Abemaciclib Impurity 55 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H36N4Si2 |
| Molecular Weight | 364.68 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 129 (CAS CATO-C4X-2937129)
- Abemaciclib impurity 113 (CAS CATO-C4X-2937113)
- Abemaciclib impurity 114 (CAS CATO-C4X-2937114)
- Abemaciclib Impurity 163 (CAS CATO-C4X-2937163)
- Abemaciclib Impurity 85 (CAS CATO-C4X-293785)
- Abemaciclib Impurity 182 (CAS CATO-C4X-2937182)
- Abemaciclib Impurity 153 (CAS CATO-C4X-2937153)
- Abemaciclib Impurity 28 (CAS CATO-C4X-293728)
Recommended Standards
- 1-Hexacosene (CAS 18835-33-1)
- 2,4,5-Trichloro-N-phenethylbenzenesulfonamide (CAS 457960-81-5)
- Hexacosene (CAS 64808-91-9)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(3-(trifluoromethyl)phenyl)acetonitrile (CAS 338407-22-0)
- Pitavastatin Impurity 41 (CAS CATO-C4X-103741)
- Pazufloxacin Impurity 11 (CAS 165071-10-3)
- Peficitinib Impurity 23 (CAS 2055576-50-4)
- 3-Bromo-2-fluorobenzoic acid (CAS 161957-56-8)
- 5-Chloro-6-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 75993-42-9)
- 4-(Chloromethyl)-2,4'-difluoro-1,1'-biphenyl (CAS 1214340-98-3)
- 1,4-Bis[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] 2-methylenebutanedioate (CAS 98452-82-5)
- (2E)-6-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hexenoic Acid Ethyl Ester (CAS 1008751-73-2)
- Lenvatinib Impurity 154 (CAS CATO-C4X-1140154)
- Tirzepatide (CAS 2023788-19-2)
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