Estradiol Benzoate EP Impurity G CAS 2393-53-5
| CAS No. | 2393-53-5 |
| Molecular Formula | C25H26O3 |
| Molecular Weight | 374.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Estradiol Benzoate EP Impurity G (CAS 2393-53-5, C25H26O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Estradiol Benzoate EP Impurity G is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 374.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H26O3 |
| Molecular Weight | 374.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estradiol Standards
- Estradiol Benzoate EP Impurity F (CAS 95870-51-2)
- Estradiol Impurity 33 (CAS CATO-C4X-163633)
- Estradiol Impurity 38 (CAS 4966-70-5)
- Estradiol Valerate impurity 21 (CAS 1313382-32-9)
- Estradiol Valerate EP Impurity (CAS 1313382-26-1)
- Estradiol Benzoate EP Impurity D (CAS 983-30-2)
- Estradiol Benzoate EP Impurity E (CAS 6045-53-0)
- Estradiol benzoate (CAS 50-50-0)
Recommended Standards
- Diethyl 5,5'-methylenebis(4-ethyl-3-methyl-1H-pyrrole-2-carboxylate) (CAS 6305-93-7)
- Cicaprost (CAS 94079-80-8)
- L-Methionine-d3-N-FMOC (S-methyl-d3) (CAS 502692-58-2)
- Cannabielsoic Acid A (CAS 26674-02-2)
- Tadalafil Impurity 157 (CAS CATO-C4X-1087157)
- Everolimus Impurity 45 (CAS CATO-C4X-112245)
- Propafenone Impurity 36 (CAS CATO-C4X-132236)
- (αS,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanenitrile (CAS 170862-36-9)
- 3-fluoro-5-hydroxy-1,4-dihydropyridin-4-one (CAS 1184172-13-1)
- 4-(4-Chloro-pyrimidin-2-ylamino)-cyclohexanol (CAS 1261233-64-0)
- tert-Butyl 8-cyano-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (CAS 1352087-38-7)
- 1-[2-(4-aminophenyl)ethyl]piperidin-4-ol (CAS 925921-12-6)
- 6-Benzyl-2-(2-methoxyethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (CAS 1251033-71-2)
- Semaglutide impurity 37 (CAS CATO-C4X-222637)
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