Estradiol Impurity 38 CAS 4966-70-5
| CAS No. | 4966-70-5 |
| Molecular Formula | C23H34O4 |
| Molecular Weight | 374.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Estradiol Impurity 38 (CAS 4966-70-5, C23H34O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H34O4, Estradiol Impurity 38 contains a flavonoid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 374.51 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H34O4 |
| Molecular Weight | 374.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Estradiol Standards
- Estradiol Impurity 33 (CAS CATO-C4X-163633)
- Estradiol Benzoate EP Impurity G (CAS 2393-53-5)
- Estradiol Benzoate EP Impurity F (CAS 95870-51-2)
- Estradiol Benzoate EP Impurity D (CAS 983-30-2)
- Estradiol Benzoate EP Impurity E (CAS 6045-53-0)
- Estradiol benzoate (CAS 50-50-0)
- Estradiol Valerate impurity 21 (CAS 1313382-32-9)
- Estradiol Valerate EP Impurity (CAS 1313382-26-1)
Recommended Standards
- Amisulpride-d5 (CAS 1216626-17-3)
- Calcitroic Acid (CAS 71204-89-2)
- N-Biotinyl-3,6-dioxa-1,8-octanediamine (CAS 138529-46-1)
- Progesterone Impurity 36 (CAS 88128-61-4)
- Atrasentan Impurity 190 (CAS CATO-C4X-3347190)
- Propofol Impurity 59 (CAS CATO-C4X-147359)
- Norethisterone Acetate EP Impurity E (CAS 66964-58-7)
- 4-Amino-5-bromopyridin-2-ol (CAS 1805444-12-5)
- 3,5-Dibromo-6-methoxy-2-aminopyrazine (CAS 1427500-63-7)
- (4-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)phenyl)methanol (CAS 1216548-30-9)
- 4-((1H-Imidazol-4-yl)methyl)-2,5-diethyloxazole (CAS 775272-13-4)
- 3-Methylbut-3-en-1-yl methanesulfonate (CAS 80352-66-5)
- H-D-Ser(SO3H)-OH (F-3370.0001) (CAS 19794-48-0)
- Biotinyl-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802086-28-7)
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