Estradiol Benzoate EP Impurity D CAS 983-30-2
| CAS No. | 983-30-2 |
| Molecular Formula | C25H28O3 |
| Molecular Weight | 376.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Estradiol Benzoate EP Impurity D (CAS 983-30-2, C25H28O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Estradiol Benzoate EP Impurity D (C25H28O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Estradiol Benzoate EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H28O3 |
| Molecular Weight | 376.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estradiol Standards
- Estradiol Benzoate EP Impurity E (CAS 6045-53-0)
- Estradiol benzoate (CAS 50-50-0)
- Estradiol Impurity 33 (CAS CATO-C4X-163633)
- Estradiol Impurity 38 (CAS 4966-70-5)
- Estradiol Benzoate EP Impurity G (CAS 2393-53-5)
- Estradiol Benzoate EP Impurity F (CAS 95870-51-2)
- 17β-Estradiol-16,16,17-d3 3-Benzoate (CAS 1192354-74-7)
- Estradiol Valerate impurity 21 (CAS 1313382-32-9)
Recommended Standards
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