Naproxen Impurity 26 CAS 23981-80-8
| CAS No. | 23981-80-8 |
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Naproxen Impurity 26 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Naproxen Impurity 26 (CAS 23981-80-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H14O3 and a molecular weight of 230.26 g/mol.
Structurally, Naproxen Impurity 26 (C14H14O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 230.26 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Naproxen Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
Related Naproxen Standards
- Naproxen EP Impurity G (R-Naproxen) (CAS 23979-41-1)
- Naproxen (CAS 22204-53-1)
- Naproxen Impurity 41 (CAS CATO-C4X-170841)
- Naproxen Impurity 42 (CAS CATO-C4X-170842)
- Naproxen Impurity 7 (CAS CATO-C4X-17087)
- Naproxen Dehydro Impurity (CAS 27602-79-5)
- (S)-Naproxen-d3 (CAS 1094102-82-5)
- rac-Naproxen-13C,d3 (CAS 1216704-11-8)
Recommended Standards
- Tryptophan EP Impurity I (CAS 5470-37-1)
- Bisoprolol Impurity 93 (CAS 2350-43-8)
- （R)-Etomidate EP Impurity B (CAS 61045-91-8)
- Bisoprolol Impurity 56 (CAS 145059-66-1)
- Olaparib Impurity 22 (CAS 179897-89-3)
- Metaraminol Impurity 3 (CAS 918-44-5)
- Levosimendan Impurity 57 (CAS CATO-C4X-130857)
- 4-Methyl-N-(pentan-3-yl)cyclohexan-1-amine (CAS 1019472-56-0)
- Trazodone EP Impurity B (CAS 62337-66-0)
- 2-Methoxybenzenesulfonic acid (CAS 34256-00-3)
- 1-(1-Methyl-1h-pyrrol-2-yl)cyclopropane-1-carbonitrile (CAS 1427020-46-9)
- Tamsulosin Impurity 24 HCl (CAS CATO-C4X-118724)
- 5-Bromo-2,6-dichloro-N-(4-fluorophenyl)-4-pyrimidinamine (CAS 2153962-20-8)
- Semaglutide impurity 55 (CAS CATO-C4X-222655)
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