Amlodipine Besylate EP Impurity D Hydrochloride CAS 2414962-06-2
| CAS No. | 2414962-06-2 |
| Molecular Formula | C20H23ClN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Amlodipine Besylate EP Impurity D Hydrochloride is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Amlodipine Besylate EP Impurity D Hydrochloride (CAS 2414962-06-2) is a certified pharmaceutical impurity reference standard with the molecular formula C20H23ClN2O5HCl and a molecular weight of 443.32 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Amlodipine Besylate EP Impurity D Hydrochloride is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 443.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Amlodipine Besylate EP Impurity D Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H23ClN2O5 HCl |
| Molecular Weight | 443.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity N32 (CAS 103094-30-0)
- (R)-Amlodipine (CAS 103129-81-3)
- Amlodipine (S)-Isomer (CAS 103129-82-4)
- Amlodipine Impurity N5 (CAS 107812-86-2)
- Amlodipine Impurity N2 (CAS 111429-90-4)
- Amlodipine Besylate (CAS 111470-99-6)
- Amlodipine Impurity N4 (CAS 113994-36-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- Brivudine Impurity C17 (CAS 74131-08-1)
- Melitracen Impurity 4 (CAS 926-63-6)
- Daclatasvir Impurity 13 (CAS CATO-C4X-184813)
- Boc-Leu-Pro-OH (CAS 64205-66-9)
- 1-Bromo-1,2,3,4-tetrahydronaphthalene (CAS 75238-77-6)
- 3,6-Diphenyl-3,4-dihydro-1H-[1,3,5]triazine-2-thione (CAS 130925-08-5)
- 8-Ethyl-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(1H)-one (CAS 863193-67-3)
- 2,9-Dibutyl-1,10-phenanthroline (CAS 85575-93-5)
- Clocapramine Dihydrochloride (CAS 28058-62-0)
- (Des-Bromo)-Neuropeptide B (1-23) (human) (CAS 434897-64-0)
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