Amlodipine Impurity N4 CAS 113994-36-8
| CAS No. | 113994-36-8 |
| Molecular Formula | C18H21ClN2O3 |
| Molecular Weight | 348.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Amlodipine Impurity N4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Amlodipine Impurity N4 (CAS 113994-36-8, C18H21ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Amlodipine Impurity N4 (C18H21ClN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H21ClN2O3 |
| Molecular Weight | 348.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity N22 (CAS 39562-06-6)
- Amlodipine Impurity 138 (CAS CATO-C4X-1095138)
- Amlodipine Impurity 115 (CAS 20236-47-9)
- Amlodipine impurity 126 (CAS CATO-C4X-1095126)
- Amlodipine EP Impurity G (CAS 43067-01-2)
- Amlodipine Impurity 71 (CAS 114011-50-6)
- Amlodipine Impurity 23 (CAS 34148-67-9)
- Amlodipine Besylate Impurity 47 (CAS 1621516-91-3)
Recommended Standards
- tert-Butyl 4-(3-chloroquinoxalin-2-yl)piperazine-1-carboxylate (CAS 651047-41-5)
- 2-((4-Chlorobenzyl)thio)-4-oxo-4-(p-tolyl)butanoic acid (CAS 301193-81-7)
- N-(7-Chloro-3-propionamidoquinoxalin-2-yl)hexanamide (CAS 61929-12-2)
- 2,4,5-Tribromothiophene-3-carbaldehyde (CAS 61200-58-6)
- Loratadine EP Impurity 39 (CAS 609806-38-4)
- Piperacillin Impurity 37 (CAS CATO-C4X-173237)
- Resmetirom impurity 81 (CAS CATO-C4X-291281)
- 2-(3-Hydroxy-1,1-dioxidotetrahydrothiophen-3-yl)acetic acid (CAS 1339871-56-5)
- Epinastine Impurity 19 (CAS 5840-40-4)
- 2-(4-Carbamoylpiperidin-1-yl)-2-phenylacetic acid (CAS 938149-72-5)
- trans-3-Methylcyclopentanol (CAS 5590-95-4)
- 4,6-Dimethoxybenzofuran-2-carbaldehyde (CAS 108639-48-1)
- Tert-butyl 4-(6-chloropyridin-2-yl)piperazine-1-carboxylate (CAS 1239369-20-0)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com