Tadalafil Impurity N23 CAS 951661-84-0
| CAS No. | 951661-84-0 |
| Molecular Formula | C22H20ClN3O4 |
| Molecular Weight | 425.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tadalafil Impurity N23 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Tadalafil Impurity N23 (CAS 951661-84-0), a pharmacopoeial impurity reference standard (molecular formula C22H20ClN3O4, MW 425.86 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C22H20ClN3O4, Tadalafil Impurity N23 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 425.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tadalafil Impurity N23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H20ClN3O4 |
| Molecular Weight | 425.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
- Tadalafil Impurity 24 (CAS 951661-81-7)
- Tadalafil Impurity 70 (CAS CATO-C4X-108770)
- Tadalafil impurity 10 (CAS 629652-40-0)
- Tadalafil Impurity 16 (CAS 629652-44-4)
- Tadalafil Impurity 17 (CAS 629652-42-2)
- Tadalafil Impurity 37 (CAS 171489-59-1)
- Tadalafil Impurity 67 (CAS CATO-C4X-108767)
- Tadalafil Impurity 84 (CAS CATO-C4X-108784)
Recommended Standards
- N-(4-chlorobenzyl)-2-((3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)thio)acetamide (CAS 626221-53-2)
- 3-Amino-N-(4-chlorobenzyl)-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide (CAS 626227-31-4)
- (4-(4-Chlorophenyl)piperazin-1-yl)(6-(trifluoromethyl)thieno[3,2-b]pyridin-2-yl)methanone (CAS 303997-59-3)
- Epitizide (CAS 1764-85-8)
- Urapidil Impurity 38 (CAS CATO-C4X-192438)
- Malic Acid Impurity 4 (CAS 56235-92-8)
- Cyproheptadine impurity 13 (CAS CATO-C4X-150613)
- 2-(2,6-Dimethoxyphenoxy)-1-phenylethan-1-one (CAS 19514-00-2)
- 5-Chlorothiazolo[5,4-d]pyrimidin-2(1H)-one (CAS 120209-32-7)
- (1R,2R,3S,4R,5R,6R)-4,5,6-Trihydroxycyclohexane-1,2,3-triyl tris(dihydrogen phosphate) (CAS 114488-20-9)
- Bilastine Impurity 19 (CAS 202189-81-9)
- 3-(Pyrrolidin-3-yl)-1,2-oxazole (CAS 1368127-11-0)
- 4-(Difluoromethyl)-6-fluoro-5-methylpicolinoyl chloride (CAS 1805294-35-2)
- Pancreatic Polypeptide (human) trifluoroacetate salt (CAS 75976-10-2)
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