Leflunomide EP Impurity H CAS 24522-30-3
| CAS No. | 24522-30-3 |
| Molecular Formula | C10H7F3N2O |
| Molecular Weight | 228.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Leflunomide EP Impurity H (CAS 24522-30-3), a pharmacopoeial impurity reference standard (molecular formula C10H7F3N2O, MW 228.17 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Leflunomide EP Impurity H is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 228.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C10H7F3N2O |
| Molecular Weight | 228.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Leflunomide Standards
- Leflunomide Impurity 21 (CAS 202057-74-7)
- Leflunomide Impurity 25 (CAS CATO-C4X-167325)
- Leflunomide EP Impurity G (CAS 724429-16-7)
- Leflunomide Impurity 2 (CAS 827029-20-9)
- Leflunomide (CAS 75706-12-6)
- Leflunomide EP Impurity C (CAS 61643-23-0)
- Leflunomide EP Impurity E (CAS 208401-20-1)
- Leflunomide EP Impurity F (CAS 1403564-06-6)
Recommended Standards
- N’-[(tert-butoxy)carbonyl]-2,2,2-trifluoroacetohydrazide (CAS 862713-98-2)
- Dimethyl (2-oxo-2-phenylethyl)phosphonate (CAS 1015-28-7)
- N-[4-(Cyanomethyl)phenyl]-2,2,2-trifluoroacetamide (CAS 63898-17-9)
- Ethyl 4-amino-2-fluoro-5-nitrobenzoate (CAS 1219014-07-9)
- Levofloxacin Impurity 40 (CAS 106939-30-4)
- Tenofovir disoproxil Impurity 14 (CAS 1244022-56-7(Free Base))
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- (E)-Benzhexol Impurity 12 HCl (CAS 67562-42-9 (free base))
- 7-Chloro-N-(2-(dimethylamino)ethyl)benzo[c][1,2,5]oxadiazole-4-sulfonamide (CAS 664985-43-7)
- 2-Azabicyclo[2.2.2]Octan-4-amine (CAS 2306274-41-7)
- (S)-2-Amino-6-methylheptane (CAS 70419-10-2)
- 4-Bromo-2-methyl-N-(2,2,2-trifluoroethyl)aniline (CAS 1021135-55-6)
- CAS 83176-59-4 (CAS 83176-59-4)
- 69558-55-0 O3Y80ZF13F Thymopentin Thymopentin [USAN:INN:BAN] L-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- L-Tyrosine, N-(N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- Thymopentine [French] Thymopentinum [Latin] Timopentina [Spanish] Thymopoietin 32-36 TP-5 Thymopoietin pentapeptide ORF-15244 Thymopentine Thymopentinum Timopentina ORF 15244 UNII-O3Y80ZF13F (CAS 69558-55-0)
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