Fosaprepitant Impurity 12 CAS 2035475-10-4
| CAS No. | 2035475-10-4 |
| Molecular Formula | C30H28F7N4O6P |
| Molecular Weight | 704.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Fosaprepitant Impurity 12 (C30H28F7N4O6P) is characterized by a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Fosaprepitant Impurity 12 (CAS 2035475-10-4, C30H28F7N4O6P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fosaprepitant Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H28F7N4O6P |
| Molecular Weight | 704.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 22 (CAS CATO-C4X-116822)
- Fosaprepitant Impurity 42 (CAS CATO-C4X-116842)
- Fosaprepitant Impurity 44 (CAS CATO-C4X-116844)
- Fosaprepitant Impurity 45 (CAS CATO-C4X-116845)
- Fosaprepitant Impurity 34 (CAS CATO-C4X-116834)
- Fosaprepitant Impurity 52 (CAS CATO-C4X-116852)
- Fosaprepitant impurity 10 (CAS CATO-C4X-116810)
- Fosaprepitant Impurity 35 (CAS CATO-C4X-116835)
Recommended Standards
- Aprepitant Impurity 73 (CAS CATO-C4X-114173)
- Aprepitant impurity 61 (CAS 889852-02-2)
- Tosufloxacin impurity 5 (CAS CATO-C4X-19765)
- Lifitegrast Impurity 125 (CAS CATO-C4X-2409125)
- Captopril impurity 1 (CAS CATO-C4X-11901)
- Pregabalin Impurity 111 (CAS CATO-C4X-1312111)
- Ziprasidone Impurity 13 (CAS CATO-C4X-124013)
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- 4-bromoisoxazol-3-amine (CAS 1519318-68-3)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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