Empagliflozin impurity 186 CAS 2452301-28-7
| CAS No. | 2452301-28-7 |
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Empagliflozin impurity 186 (CAS 2452301-28-7, C23H27ClO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Empagliflozin impurity 186 (C23H27ClO7) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Empagliflozin impurity 186 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 02 (CAS 1620758-31-7&1620758-32-8)
- Empagliflozin (CAS 864070-44-0)
- Empagliflozin Impurity 1 (CAS 864070-43-9)
- Empagliflozin Impurity 10 (CAS 2452301-42-5)
- Empagliflozin Impurity 117 (CAS CATO-C4X-1065117)
- Empagliflozin Impurity 118 (CAS CATO-C4X-1065118)
- Empagliflozin Impurity 13 (CAS CATO-C4X-106513)
- Empagliflozin Impurity 131 (CAS CATO-C4X-1065131)
Recommended Standards
- Empagliflozin Impurity 16 (CAS 1620758-32-8)
- Empagliflozin impurity 196 (CAS CATO-C4X-1065196)
- Empagliflozin Impurity 137 (CAS CATO-C4X-1065137)
- Empagliflozin impurity 197 (CAS CATO-C4X-1065197)
- Hyoscyamine Impurity 5 (CAS CATO-C4X-34375)
- Clopidogrel Impurity 987 (CAS CATO-C4X-1029987)
- Atorvastatin EP Impurity E(Calcium salt) (CAS 1105067-88-6)
- cis-Vitamin K1-d7 (CAS 16033-41-3 (non-labelled))
- 3,3'-Oxybis(propane-1,2-diol) (CAS 627-82-7)
- Bis(imidazolidin-2-one) hydrate (CAS 121325-67-5)
- Levonorgestrel EP Impurity G (CAS 87585-03-3)
- 2,3-Dihydro-1h-indene-1-sulfonyl chloride (CAS 1248712-81-3)
- 4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylic acid (CAS 532391-89-2)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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