Empagliflozin impurity 181 CAS 2452301-36-7
| CAS No. | 2452301-36-7 |
| Molecular Formula | C23H27ClO8 |
| Molecular Weight | 466.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 466.91 g/mol gives Empagliflozin impurity 181 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Empagliflozin impurity 181 (CAS 2452301-36-7) is a certified pharmaceutical impurity reference standard with the molecular formula C23H27ClO8 and a molecular weight of 466.91 g/mol.
Based on its molecular formula C23H27ClO8, Empagliflozin impurity 181 contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 466.91 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H27ClO8 |
| Molecular Weight | 466.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 170 (CAS 1620758-30-6)
- Empagliflozin impurity 188 (CAS CATO-C4X-1065188)
- Empagliflozin impurity 189 (CAS CATO-C4X-1065189)
- Empagliflozin impurity 206 (CAS CATO-C4X-1065206)
- Empagliflozin impurity 210 (CAS CATO-C4X-1065210)
- Empagliflozin Impurity 218 (CAS CATO-C4X-1065218)
- Empagliflozin impurity 224 (CAS CATO-C4X-1065224)
- Empagliflozin Impurity 49 (CAS 1279691-35-8)
Recommended Standards
- Ethyl 5-[({1-[(1Z)-{[(4-chlorophenyl)methoxy]imino}methyl]naphthalen-2-yl}oxy)methyl]-4,5-dihydro-1,2-oxazole-3-carboxylate (CAS 321432-26-2)
- (2E)-3-Amino-3-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-cyano-N-phenylprop-2-enethioamide (CAS 338959-69-6)
- (S)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-nitrophenyl)-1,2-dihydroisoquinolin-3(4H)-one (CAS 1821463-87-9)
- 1-(4-Chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-nitrophenyl)-1,2-dihydroisoquinolin-3(4H)-one (CAS 1821463-86-8)
- Umeclidinium Impurity 7 (CAS CATO-C4X-13397)
- Semaglutide impurity 290 (CAS CATO-C4X-2226290)
- Benzbromarone Impurity 13 (CAS 51073-15-5)
- N-(3-thioxo-3H-1,2,4-dithiazol-5-yl)acetamide (CAS 23405-40-5)
- 2-Chloro-N-(2,4,5-trichlorophenyl)acetamide (CAS 23595-42-8)
- Methyl 4-aminobenzo[b]thiophene-2-carboxylate (CAS 330801-72-4)
- 4-(Pyridin-4-yl)pyrimidine-2-thiol (CAS 874779-72-3)
- Ethyl 2-(2-chloro-5-methylphenoxy)acetate (CAS 588679-09-8)
- 3-Amino-5-ethyl-1H-pyrazole-4-carboxamide (CAS 50436-86-7)
- Hexapeptide-11 (CAS 100684-36-4)
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