Diclofenac Impurity 45 CAS 24542-74-3
| CAS No. | 24542-74-3 |
| Molecular Formula | C14H7Cl2NO2 |
| Molecular Weight | 292.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 292.12 g/mol gives Diclofenac Impurity 45 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Diclofenac Impurity 45 (CAS 24542-74-3, C14H7Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Diclofenac Impurity 45 (C14H7Cl2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Diclofenac Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H7Cl2NO2 |
| Molecular Weight | 292.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Impurity 22 (CAS CATO-C4X-105122)
- Diclofenac Impurity 25 (CAS CATO-C4X-105125)
- Diclofenac Impurity 16 (CAS 146607-19-4)
- Diclofenac Acid (CAS 15307-86-5)
- Diclofenac-d4 (phenyl-d4-acetic) (CAS 153466-65-0)
- Diclofenac Impurity 43 (CAS CATO-C4X-105143)
- Diclofenac Sodium Impurity 34 (CAS 123790-84-1)
- Diclofenac Sodium Impurity 35 (CAS 13625-57-5)
Recommended Standards
- CAS 21231-80-1 (CAS 21231-80-1)
- Metoclopramide Impurity 11 (CAS 111049-74-2)
- tert-Butyl 2,6-dichloro-4-nitrobenzoate (CAS 336818-33-8)
- 4-(6-Bromo-pyridin-2-yl)-2-methyl-benzoic acid (CAS 1020718-62-0)
- Otilonium Bromide Impurity 3 (CAS 14629-01-7)
- Cefoperazone Impurity 13 (CAS CATO-C4X-114913)
- Latamoxef Impurity 16 (CAS CATO-C4X-179816)
- NαBoc-Nt-tritylhistamine (CAS 327160-17-8)
- 2-Phenylquinoxaline-5-carboxylic acid (CAS 904813-44-1)
- (E)-3-Ethylidenebenzofuran-2(3H)-one (CAS 114524-40-2)
- 2-(4,5,6,7-Tetrahydro-1H-benzo[d][1,2,3]triazol-1-yl)acetic acid (CAS 1266941-01-8)
- (4-cyclopropyl-5-methyl-4H-1,2,4-triazol-3-yl)methanamine dihydrochloride (CAS 1432679-11-2)
- 2,3-Dimethoxy-6-nitropyridine (CAS 79491-44-4)
- Des-Val23-Tirzepatide (CAS CATO-CPTD788950)
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