Diclofenac Impurity 22 CAS CATO-C4X-105122
| CAS No. | CATO-C4X-105122 |
| Molecular Formula | C15H11Cl2NO |
| Molecular Weight | 292.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Diclofenac Impurity 22.
Diclofenac Impurity 22 (CAS CATO-C4X-105122) is a certified pharmaceutical impurity reference standard with the molecular formula C15H11Cl2NO and a molecular weight of 292.16 g/mol.
The molecular framework of Diclofenac Impurity 22 (C15H11Cl2NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Diclofenac Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11Cl2NO |
| Molecular Weight | 292.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Impurity 25 (CAS CATO-C4X-105125)
- Diclofenac Impurity 45 (CAS 24542-74-3)
- Diclofenac Impurity 16 (CAS 146607-19-4)
- Diclofenac Acid (CAS 15307-86-5)
- Diclofenac-d4 (phenyl-d4-acetic) (CAS 153466-65-0)
- Diclofenac Impurity 43 (CAS CATO-C4X-105143)
- Diclofenac Sodium Impurity 34 (CAS 123790-84-1)
- Diclofenac Sodium Impurity 35 (CAS 13625-57-5)
Recommended Standards
- tert-butyl (3,5-dichloro-4-hydroxybenzyl)carbamate (CAS CATO-C3D-262937)
- Swinholide A, Theonella Swinhoei (CAS 95927-67-6)
- Meclofenoxate Impurity 6 (CAS CATO-C4X-24696)
- Perfluorophenyl 1-methyl-1H-pyrazole-5-carboxylate (CAS 926921-64-4)
- Ammoxetine Impurity 7 (CAS CATO-C4X-33577)
- Indometacin Impurity 44 (CAS CATO-C4X-147044)
- Finerenone Impurity 244 (CAS 13444-19-4)
- 1-Methyl-4-(5-methyl-4-(2-(piperidin-1-yl)ethyl)-4H-1,2,4-triazol-3-yl)-1H-pyrazol-5-amine (CAS 957010-46-7)
- tert-Butyl 3-(2-aminoethyl)-5-chloro-1h-indole-1-carboxylate (CAS 1421321-68-7)
- 1-(2,4-Dinitrophenyl)piperidine-3-carboxylic acid (CAS 325702-00-9)
- 3-(4-Bromo-2-fluorophenyl)-2-chloro-1-propene (CAS 951894-13-6)
- Myricoside (CAS 76076-04-5)
- 645414-25-1 Acantrifoside E (CAS 645414-25-1)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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