Naproxen Impurity 6 CAS 174172-95-3
| CAS No. | 174172-95-3 |
| Molecular Formula | C12H19NO2 |
| Molecular Weight | 209.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Naproxen Impurity 6 (C12H19NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Naproxen Impurity 6 (CAS 174172-95-3) is a certified pharmaceutical impurity reference standard with the molecular formula C12H19NO2 and a molecular weight of 209.28 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19NO2 |
| Molecular Weight | 209.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Nitrogen Atoms | 1 |
Related Naproxen Standards
Recommended Standards
- Gabapentin Impurity 39 (CAS CATO-C4X-165439)
- Nicardipine Impurity 36 (CAS 115972-93-5)
- Metoprolol EP Impurity F (CAS 7695-63-8)
- Verapamil EP Impurity C (CAS 3490-05-9)
- Emtricitabine Impurity B (CAS CATO-C4X-123237)
- Nemonoxacin Impurity 81 (CAS CATO-C4X-312881)
- Octreotide EP Impurity H Acetate (CAS 173606-11-6)
- 2-((tert-Butoxycarbonyl)amino)-3-chloro-5-fluorobenzoic acid (CAS 2248356-39-8)
- 6-((3,5-Bis(trifluoromethyl)benzyl)thio)imidazo[2,1-b]thiazole-5-carbonitrile (CAS 400080-16-2)
- diethyl 2-[(2-chloro-4-fluoroanilino)methylene]malonate (CAS 185010-90-6)
- (3R,4R)-3-(2,2-Dibromoethenyl)-4-methyl-4-[2-(triethylsilyl)ethynyl]cyclohexene (CAS 1448446-16-9)
- Isopropyl 4-(4-(aminomethyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (CAS 1206969-26-7)
- 1-(4-tert-Butylphenyl)-3-(2-chlorophenyl)-1-[(2,4-dimethoxyphenyl)methyl]thiourea (CAS 306730-48-3)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com