Naproxen Impurity 40 CAS 36815-04-0
| CAS No. | 36815-04-0 |
| Molecular Formula | C13H12O2 |
| Molecular Weight | 200.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Naproxen Impurity 40.
As a process- or degradation-related impurity, Naproxen Impurity 40 (CAS 36815-04-0, C13H12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Naproxen Impurity 40 (C13H12O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12O2 |
| Molecular Weight | 200.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
Related Naproxen Standards
- Naproxen EP Impurity L (CAS 3900-45-6)
- Naproxen Impurity 29 (CAS 17056-94-9)
- Naproxen Impurity 32 (CAS 5672-94-6)
- Naproxen Impurity 52 (CAS CATO-C4X-170852)
- Naproxen Impurity 16 (CAS 34352-92-6)
- Naproxen EP Impurity O (CAS 2471-70-7)
- Naproxen EP Impurity K (CAS 77301-42-9)
- Naproxen Impurity 53 (CAS 150493-03-1)
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