Naproxen EP Impurity K CAS 77301-42-9
| CAS No. | 77301-42-9 |
| Molecular Formula | C13H14O2 |
| Molecular Weight | 202.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Naproxen EP Impurity K meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Naproxen EP Impurity K (CAS 77301-42-9) is a certified pharmaceutical impurity reference standard with the molecular formula C13H14O2 and a molecular weight of 202.25 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Naproxen EP Impurity K is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H14O2 |
| Molecular Weight | 202.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
Related Naproxen Standards
- Naproxen EP Impurity O (CAS 2471-70-7)
- Naproxen EP Impurity L (CAS 3900-45-6)
- Naproxen Impurity 29 (CAS 17056-94-9)
- Naproxen Impurity 32 (CAS 5672-94-6)
- Naproxen Impurity 40 (CAS 36815-04-0)
- Naproxen Impurity 52 (CAS CATO-C4X-170852)
- Naproxen Impurity 16 (CAS 34352-92-6)
- Naproxen Impurity 6 (CAS 174172-95-3)
Recommended Standards
- Glycopyrrolate Impurity 6 (CAS 126497-27-6)
- Butylphthalide Impurity 18 (CAS CATO-C4X-181318)
- Ondansetron Impurity 15 (CAS 27385-45-1)
- Butylphthalide Impurity 76 (CAS 90965-68-7)
- Samidorphan Impurity 11 (CAS 886588-57-4)
- Azilsartan Impurity 93 (CAS 1800532-35-7)
- Clozapine EP Impurity B (CAS 263366-81-0)
- 1-Cyclopentylpiperidin-4-amine dihydrochloride (CAS 952201-42-2)
- (2S,3R,4E)-2-Butyrylamino-4-hepten-1,3-diol 1644541-00-3 (CAS 1644541-00-3)
- Methyl 3,5-bis({1-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl}methoxy)benzoate (CAS 866039-44-3)
- 1,1,2-Trifluoropropane (CAS 66794-35-2)
- Trans-2-(4-cyanophenyl)cyclopropanecarboxylicacid (CAS 1119807-15-6)
- N4,N4-Dimethyl-2-morpholinopyrimidine-4,5-diamine (CAS 2090867-03-9)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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