Bortezomib Impurity C44 HCI CAS 2493017-06-2
| CAS No. | 2493017-06-2 |
| Molecular Formula | C11H24BNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bortezomib Impurity C44 HCI.
As a process- or degradation-related impurity, Bortezomib Impurity C44 HCI (CAS 2493017-06-2, C11H24BNO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bortezomib Impurity C44 HCI (C11H24BNO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of -0.5, corresponding to approximately 0 ring(s) or double-bond equivalent(s). With a molecular weight of 249.59 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H24BNO2 HCl |
| Molecular Weight | 249.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | -0.5 |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bortezomib Standards
- Bortezomib Impurity 77 (CAS 103435-88-7)
- Bortezomib Impurity 36 (CAS 1093959-75-1)
- Bortezomib Impurity 35 (CAS 1104011-35-9)
- Bortezomib Impurity 45 (CAS 110755-29-8)
- Bortezomib Impurity 6 (CAS 1132709-14-8)
- Bortezomib Impurity 7 (CAS 1132709-15-9)
- Bortezomib Impurity 5 (CAS 1132709-16-0)
- Bortezomib Impurity 2 (CAS 114457-94-2)
Recommended Standards
- Bosentan Impurity 21 (CAS CATO-C4X-156421)
- Oxytocin Impurity 44 (CAS CATO-C4X-206644)
- Ponatinib Impurity 35 (CAS CATO-C4X-226935)
- Cyclopentyl-piperidin-4-yl-amine (CAS 886506-60-1)
- 5-(M-tolyloxy)furan-2-carbaldehyde (CAS 1082167-88-1)
- 2-(1-Chloropropan-2-yl)-1,3-dioxolane (CAS 35502-17-1)
- Doxofylline Impurity 28 (CAS 62637-09-6)
- 1-(4-((5-Aminopentyl)amino)quinolin-3-yl)-2,2,2-trifluoroethanone hydrochloride (CAS 1956326-73-0)
- 9-Oxo-9,10-dihydroacridine-4-carboxylic Acid (CAS 24782-64-7)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
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