Bortezomib Impurity 2 CAS 114457-94-2
| CAS No. | 114457-94-2 |
| Molecular Formula | C14H13N3O3 |
| Molecular Weight | 271.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Bortezomib Impurity 2 (CAS 114457-94-2, C14H13N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bortezomib Impurity 2 (C14H13N3O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H13N3O3 |
| Molecular Weight | 271.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 3 |
Related Bortezomib Standards
- Bortezomib Impurity 31 (CAS 1608986-16-8)
- Bortezomib Impurity 1 (CAS 289472-80-6)
- Bortezomib Impurity 36 (CAS CATO-C4X-107236)
- Bortezomib Impurity 61 (CAS CATO-C4X-107261)
- Bortezomib Impurity 80 (CAS 179324-86-8)
- Bortezomib Impurity 49 (CAS 948294-96-0)
- Bortezomib Impurity 40 (CAS 87304-47-0)
- Bortezomib Impurity N46 (CAS 85167-14-2)
Recommended Standards
- 898785-85-8 Methyl 4-(2-methoxypyridine-3-carbonyl)benzoate DTXSID10642157 (CAS 898785-85-8)
- 898785-81-4 Methyl 2-(2-methoxypyridine-3-carbonyl)benzoate DTXSID90642155 (CAS 898785-81-4)
- Alogliptin Impurity 60 (CAS 2514763-78-9)
- 3-((2-methylbenzofuro[3,2-d]pyrimidin-4-yl)amino)propanoic acid 848728-92-7 F2117-0014 (CAS 848728-92-7)
- Drotaverin Impurity 61 (CAS CATO-C4X-243561)
- Ipratropium Bromide Impurity 33 (CAS 2784-21-6)
- Letermovir Impurity 50 (CAS CATO-C4X-291550)
- Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-(methyl(3-methyloxetan-3-yl)amino)nicotinate (CAS 1137476-04-0)
- Potassium trifluoro(3-(4-methyl-1,4-diazepan-1-yl)prop-1-en-2-yl)borate (CAS 1357559-45-5)
- Piromelatine, 98% (CAS 946846-83-9)
- N-(Chloroacetyl)1-naphtylamine (CAS 832-89-3)
- 4-(2-(Dimethylamino)ethoxy)benzimidamide dihydrochloride (CAS 1269152-07-9)
- 2-Amino-5-iodo-6-methylpyrimidin-4(3H)-one (CAS 22294-57-1)
- Anti-Inflammatory Peptide 3 (CAS 118850-73-0)
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