Bortezomib Impurity 45 CAS 110755-29-8
| CAS No. | 110755-29-8 |
| Molecular Formula | C14H22N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Bortezomib Impurity 45 (CAS 110755-29-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2OC2F3O2 and a molecular weight of 347.36 g/mol.
Structurally, Bortezomib Impurity 45 (C14H22N2OC2F3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.5, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 347.36 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Bortezomib Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H22N2O C2F3O2 |
| Molecular Weight | 347.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Bortezomib Standards
- Bortezomib Impurity 77 (CAS 103435-88-7)
- Bortezomib Impurity 36 (CAS 1093959-75-1)
- Bortezomib Impurity 35 (CAS 1104011-35-9)
- Bortezomib Impurity 6 (CAS 1132709-14-8)
- Bortezomib Impurity 7 (CAS 1132709-15-9)
- Bortezomib Impurity 5 (CAS 1132709-16-0)
- Bortezomib Impurity 2 (CAS 114457-94-2)
- Bortezomib Impurity 51 (CAS 1194235-14-7)
Recommended Standards
- LCZ-696 Impurity 17(S,S) (CAS 1012341-52-4)
- Paliperidone Impurity 127 (CAS CATO-C4X-1724127)
- Rivaroxaban Impurity 90 (CAS 59614-95-8)
- 3-Cyclopropoxy-N5-methylpyridine-2,5-dicarboxamide (CAS 1243468-11-2)
- 4,4'-((4-Iminocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-methylaniline) (CAS 682730-74-1)
- Rupatadine Impurity 20 (CAS 1422960-88-0)
- 3-Butylidene-7-methylimidazo[1,2-a]pyrimidine-2,5(1H,3H)-dione (CAS 61593-28-0)
- (S)-4-KETO-PROLINE HYDROBROMIDE (S)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID HYDROBROMIDE 4-KETO-L-PROLINE HYDROBROMIDE 4-OXO-L-PROLINE HYDROBROMIDE 75776-67-9 BC003842 (CAS 75776-67-9)
- 2-(2,6-Diisopropylphenyl)isoquinoline-1,3(2H,4H)-dione (CAS 182800-53-9)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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