Neostigmine EP Impurity A Iodide CAS 2498-27-3
| CAS No. | 2498-27-3 |
| Molecular Formula | C9H14NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 279.12 g/mol gives Neostigmine EP Impurity A Iodide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Neostigmine EP Impurity A Iodide (CAS 2498-27-3) is a certified pharmaceutical impurity reference standard with the molecular formula C9H14NOI and a molecular weight of 279.12 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, iodine substitution, Neostigmine EP Impurity A Iodide is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 279.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H14NO I |
| Molecular Weight | 279.12 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Neostigmine Standards
- Neostigmine Bromide (CAS 114-80-7)
- Neostigmine bromide Impurity 14 (CAS 14318-66-2)
- Neostigmine Impurity 24 (CAS 15799-79-8)
- Neostigmine EP Impurity C (CAS 16088-19-0)
- Neostigmine Methyl Sulfate - Impurity A (Bromide Salt) (CAS 1620-19-5)
- Neostigmine Impurity 50 (CAS 16460-28-9)
- Neostigmine Impurity 4 (CAS 19962-04-0)
- Neostigmine impurity 31 (CAS 22237-93-0（free base）)
Recommended Standards
- Budesonide Impurity 61 (CAS 131711-17-6)
- Levosimendan Impurity 24 (CAS CATO-C4X-130824)
- Xanomeline impurity 25 (CAS CATO-C4X-330125)
- 2-Amino-6-propyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile (CAS 1251338-57-4)
- Melamine amide-<SUP>13</SUP>C<SUB>3</SUB> (CAS 1173021-81-2)
- 1-(5-Fluoro-2-propoxyphenyl)ethanol (CAS 1369203-11-1)
- (1R,3S)-3-[(Z)-2-Chloro-2-fluorovinyl]-2,2-dimethylcyclopropanecarbonyl chloride (CAS 77789-75-4)
- 7-(3,4-Dimethylphenyl)-7-oxoheptanoic acid (CAS 898788-19-7)
- 3-(5-Acetylthiophen-2-yl)benzaldehyde (CAS 893735-33-6)
- Endo-Gly4-Semaglutide (CAS CATO-C4X-222679)
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