Riociguat Impurity N3 CAS 2512205-25-1
| CAS No. | 2512205-25-1 |
| Molecular Formula | C14H12FN5 |
| Molecular Weight | 269.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Riociguat Impurity N3 (CAS 2512205-25-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H12FN5 and a molecular weight of 269.28 g/mol.
Riociguat Impurity N3 (C14H12FN5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H12FN5 |
| Molecular Weight | 269.28 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Riociguat Standards
- Riociguat Impurity N10 (CAS 2101651-50-5)
- Riociguat Impurity 24 (CAS 256376-62-2)
- Riociguat Impurity 24 (CAS 93866-45-6)
- Riociguat Impurity 26 (CAS 304874-06-4)
- Riociguat Impurity 8 (CAS 256376-65-5)
- Riociguat Impurity 13 (CAS CATO-C4X-174913)
- Riociguat Impurity N49 (CAS 256376-59-7)
- Riociguat Impurity 31 (CAS CATO-C4X-174931)
Recommended Standards
- 6-(4-Fluorobenzyl)-5-oxothiomorpholine-3-carboxylic acid (CAS 1025448-57-0)
- Vericiguat impurity 44 (CAS CATO-C4X-289644)
- 6-[(2-Fluorophenyl)methyl]-5-oxothiomorpholine-3-carboxylic acid (CAS 1032056-52-2)
- n-(5-Nitroimidazo[2,1-b]thiazol-6-yl)morpholin-4-amine (CAS 930655-05-3)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Posaconazole Impurity 271 (CAS 159276-57-0)
- Bupropion Impurity 71 (CAS 102141-12-8)
- 4-Ethoxy-2-hydroxybenzo[d]oxazole (CAS 1806284-26-3)
- 2-(4-Chloro-2-(methoxymethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2377474-13-8)
- (S)-(1-Tritylaziridin-2-yl)methyl methanesulfonate (CAS 1095273-25-8)
- (R)-1-(4-Methoxyphenyl)ethanamine hydrochloride (CAS 911373-69-8)
- 4-chloro-5-ethylthiophene-2-carboxylic acid (CAS 859794-04-0)
- 3,5-Dibromo-N,N-dimethylpyrazin-2-amine (CAS 84539-07-1)
- Des-Tyr10-Tirzepatide (CAS CATO-CPTD788680)
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