Riociguat Impurity 26 CAS 304874-06-4
| CAS No. | 304874-06-4 |
| Molecular Formula | C15H13FN4O |
| Molecular Weight | 284.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Riociguat Impurity 26.
As a process- or degradation-related impurity, Riociguat Impurity 26 (CAS 304874-06-4, C15H13FN4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Riociguat Impurity 26 (C15H13FN4O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 284.29 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H13FN4O |
| Molecular Weight | 284.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Riociguat Standards
- Riociguat Impurity 24 (CAS 93866-45-6)
- Riociguat Impurity 24 (CAS 256376-62-2)
- Riociguat Impurity N49 (CAS 256376-59-7)
- Riociguat Impurity N10 (CAS 2101651-50-5)
- Riociguat Impurity N3 (CAS 2512205-25-1)
- Riociguat Impurity 8 (CAS 256376-65-5)
- Riociguat Impurity 13 (CAS CATO-C4X-174913)
- Riociguat Impurity 31 (CAS CATO-C4X-174931)
Recommended Standards
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- R-Butyryl Carnitine Chloride (CAS 162067-50-7)
- 2-(2-Amino-phenyl)-oxazole-4-carboxylic acid (CAS 1220039-54-2)
- D-Trp25-Tirzepatide (CAS CATO-CPTD788909)
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