Riociguat Impurity 8 CAS 256376-65-5
| CAS No. | 256376-65-5 |
| Molecular Formula | C14H9FN4 |
| Molecular Weight | 252.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Riociguat Impurity 8 (CAS 256376-65-5) is a certified pharmaceutical impurity reference standard with the molecular formula C14H9FN4 and a molecular weight of 252.25 g/mol.
Structurally, Riociguat Impurity 8 (C14H9FN4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 252.25 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H9FN4 |
| Molecular Weight | 252.25 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Riociguat Standards
- Riociguat Impurity 13 (CAS CATO-C4X-174913)
- Riociguat Impurity N10 (CAS 2101651-50-5)
- Riociguat Impurity N3 (CAS 2512205-25-1)
- Riociguat Impurity 24 (CAS 256376-62-2)
- Riociguat Impurity 24 (CAS 93866-45-6)
- Riociguat Impurity 26 (CAS 304874-06-4)
- Riociguat Impurity N49 (CAS 256376-59-7)
- Riociguat Impurity N13 (CAS 6017-21-6)
Recommended Standards
- N-(4-Acetamido-1,2,5-oxadiazol-3-yl)thiophene-2-carboxamide (CAS 640238-56-8)
- Cyclophosphamide Impurity 25 (CAS 2387771-94-8)
- N-(3-Methylisothiazol-5-yl)-4-nitro-1H-pyrrole-2-carboxamide (CAS 478493-09-3)
- Cyclophosphamide impurity 35 (CAS CATO-C4X-230635)
- Tizanidine Impurity 46 (CAS CATO-C4X-144546)
- Baloxavir Impurity 67 (CAS CATO-C4X-210867)
- Atogepant Impurity 35 (CAS 1456803-47-6)
- 1,2-Dimethyl-3-oxo-5-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (CAS 3550-18-3)
- (S)-phenyl(piperidin-4-yl)methanol (CAS 957202-21-0)
- 3-(3-Methyl-1-propyl-1H-pyrazol-4-yl)propiolic acid (CAS 1354706-54-9)
- β-Estradiol 3,17-DisulfateDISCONTINUED, offer E888945 (CAS 3233-70-3)
- 1-[(4-tert-Butylphenyl)methyl]-4-nitro-1h-pyrazole (CAS 1240570-45-9)
- 2-(Aminomethyl)-N,N-dimethylaniline (CAS 57678-45-2)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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