Atovaquone EP Impurity A CAS 2517583-91-2
| CAS No. | 2517583-91-2 |
| Molecular Formula | C22H19ClO3 |
| Molecular Weight | 366.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Atovaquone EP Impurity A (CAS 2517583-91-2), a pharmacopoeial impurity reference standard (molecular formula C22H19ClO3, MW 366.84 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Atovaquone EP Impurity A (C22H19ClO3) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Atovaquone EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H19ClO3 |
| Molecular Weight | 366.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
Related Atovaquone Standards
- Atovaquone EP Impurity B (RC A) (CAS 137732-39-9)
- Atovaquone (CAS 95233-18-4)
- Atovaquone EP Impurity C (CAS 1809464-27-4)
- cis-Atovaquone-d5 (contains 10% trans isomer) (CAS 1217612-80-0)
- Atovaquone-d5 (CAS 1329792-63-3)
- Atovaquone EP Impurity D (CAS 129700-41-0)
- Atovaquone Impurity 9 (CAS 1100053-58-4)
- Atovaquone Impurity 1 (CAS 49708-81-8)
Recommended Standards
- Paichongding (CAS 948994-16-9)
- Terbutaline Impurity 79 (CAS CATO-C4X-118379)
- 2-((3-(2-Chlorophenyl)-1,2,4-thiadiazol-5-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide (CAS 864919-59-5)
- Indeno[1,2,3-de]quinoline (CAS 206-55-3)
- Rebamipide Impurity 53 (CAS CATO-C4X-152353)
- Pitavastatin Impurity 79 (CAS 2153433-73-7)
- Milnacipran Impurity 8 (CAS 6843-36-3)
- n-(4-Chlorophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 2096339-42-1)
- 2-(tert-Butyl)-5-(cyclopropylmethoxy)phenol (CAS 1243450-39-6)
- (1-((4-Bromothiophen-2-yl)methyl)pyrrolidin-2-yl)methanol (CAS 1247988-05-1)
- n-(6-Methoxybenzo[d]thiazol-2-yl)acetamide (CAS 100817-90-1)
- (5-Phenyl-1,2-oxazol-3-yl)methanol (CAS 1619-37-0)
- 5-Aminopyrimidine-2,4,6-triol hydrochloride (CAS 66887-61-4)
- Semaglutide impurity 33 (CAS CATO-C4X-222633)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com