Atovaquone EP Impurity B (RC A) CAS 137732-39-9
| CAS No. | 137732-39-9 |
| Molecular Formula | C22H19ClO3 |
| Molecular Weight | 366.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Atovaquone EP Impurity B (RC A) is closely related to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Atovaquone EP Impurity B (RC A) (CAS 137732-39-9), molecular formula C22H19ClO3 and molecular weight 366.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Atovaquone EP Impurity B (RC A) (C22H19ClO3) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Atovaquone EP Impurity B (RC A) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H19ClO3 |
| Molecular Weight | 366.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
Related Atovaquone Standards
- Atovaquone (CAS 95233-18-4)
- Atovaquone EP Impurity A (CAS 2517583-91-2)
- Atovaquone EP Impurity C (CAS 1809464-27-4)
- cis-Atovaquone-d5 (contains 10% trans isomer) (CAS 1217612-80-0)
- Atovaquone-d5 (CAS 1329792-63-3)
- Atovaquone EP Impurity D (CAS 129700-41-0)
- Atovaquone Impurity 9 (CAS 1100053-58-4)
- Atovaquone Impurity 1 (CAS 49708-81-8)
Recommended Standards
- 2-Chloro-4-[4-(1-naphthyl)phenyl]quinazoline (CAS 1373265-62-3)
- 1-(2,4-Bis(benzyloxy)-5-chlorophenyl)ethanone (CAS 705963-54-8)
- 4-(4-Chlorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326809-93-1)
- 2-((2-Cyano-3-methylbutan-2-yl)amino)-2-oxoethyl 2-(4-chlorophenoxy)-2-methylpropanoate (CAS 877974-12-4)
- (R)-(-)-Ketoprofen-13C,d3 (CAS 1329496-52-7)
- 2-Amino-3-(benzo[d][1,3]dioxol-5-yl)propanoic acid (CAS 33522-63-3)
- 4-(cyclopropylmethoxy)-3-hydroxybenzoic acid (CAS 1243391-01-6)
- (Perfluoropropane-2,2-diyl)bis(4,1-phenylene) diacrylate (CAS 108050-41-5)
- 1,1,3,5-Tetramethylcyclohexane (CAS 4306-65-4)
- Ropivacaine EP Impurity G ((R)-Ropivacaine) (CAS 98717-16-9)
- 4-(Pyridin-3-yl)thiazole (CAS 162704-76-9)
- N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxybenzamide (CAS 176379-18-3)
- n-(1h-Benzo[d]imidazol-2-yl)-4-methylbenzenesulfonamide (CAS 13068-58-1)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
Why CATO?
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