Riociguat Impurity 30 CAS 2518331-19-4
| CAS No. | 2518331-19-4 |
| Molecular Formula | C22H21FN8O4 |
| Molecular Weight | 480.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Riociguat Impurity 30 (CAS 2518331-19-4), a pharmacopoeial impurity reference standard (molecular formula C22H21FN8O4, MW 480.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Riociguat Impurity 30 (C22H21FN8O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Riociguat Impurity 30 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21FN8O4 |
| Molecular Weight | 480.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat Impurity 25 (CAS CATO-C4X-174925)
- Riociguat impurity 28 (CAS CATO-C4X-174928)
- Riociguat EP Impurity D (CAS 625115-54-0)
- Riociguat Impurity N2 （E-isomer） (CAS 370879-49-5)
- Riociguat Impurity N40 (CAS 428854-23-3)
- Riociguat Impurity 33 (CAS CATO-C4X-174933)
- Riociguat Impurity 4 (CAS CATO-C4X-17494)
- Riociguat Impurity 32 (CAS CATO-C4X-174932)
Recommended Standards
- N-(3,5-Bis(trifluoromethyl)phenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 556802-21-2)
- Apalutamide D3 (CAS 1638885-61-6)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((4-cyclohexyl-5-(2,4-dichlorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 764692-22-0)
- Astraisoflavan-7-O-β-D-glucoside (CAS 1011711-05-9)
- Lodoxamide lmpurity 13 (CAS 53882-13-6)
- Pyrilutamide Impurity N88盐酸盐 (CAS 1542258-18-3 (free base))
- Mirogabalin Impurity 105 (CAS CATO-C4X-2924105)
- N-[4-(2-Methoxyethoxy)phenyl]-N-[2-(2-methylphenoxy)butyl]amine (CAS 1040693-16-0)
- 5,5,5-Trifluoropentan-2-amine (CAS 910410-12-7)
- 4,7-Methano-1H-indene, 3a,4,7,7a-tetrahydro-, polymer with 1,3-butadiene (CAS 49603-39-6)
- 4,4-Diethoxybut-2-yn-1-ol (CAS 18350-44-2)
- 2-(3-Acetylbenzyl)-1H-indazol-3(2H)-one (CAS 89438-63-1)
- (2,6-Dimethoxybenzyl)hydrazine (CAS 1016711-22-0)
- Peptide 439 (CAS CATO-CPTD788439)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com