Riociguat Impurity N40 CAS 428854-23-3
| CAS No. | 428854-23-3 |
| Molecular Formula | C23H18FN9 |
| Molecular Weight | 439.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Riociguat Impurity N40.
As a process- or degradation-related impurity, Riociguat Impurity N40 (CAS 428854-23-3, C23H18FN9) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Riociguat Impurity N40 (C23H18FN9) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Riociguat Impurity N40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H18FN9 |
| Molecular Weight | 439.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 9 |
Related Riociguat Standards
- Riociguat Impurity N2 （E-isomer） (CAS 370879-49-5)
- Riociguat Impurity 33 (CAS CATO-C4X-174933)
- Riociguat Impurity 4 (CAS CATO-C4X-17494)
- Riociguat Impurity 32 (CAS CATO-C4X-174932)
- Riociguat EP Impurity C (CAS CATO-C4X-174914)
- Riociguat Impurity 19 (CAS CATO-C4X-174919)
- Riociguat Impurity 37 (CAS CATO-C4X-174937)
- Riociguat Impurity 40 (CAS CATO-C4X-174940)
Recommended Standards
- Vericiguat Impurity 78 (CAS CATO-C4X-289678)
- (4Z)-3-tert-Butyl-1-(4-nitrophenyl)-4-[(3,4,5-trimethoxyphenyl)methylidene]-4,5-dihydro-1H-pyrazol-5-one (CAS 1025878-53-8)
- Lestaurtinib-13CD4 (CAS 111358-88-4)
- Methyl 2-((3-(3-(trifluoromethyl)phenyl)quinolin-2-yl)thio)benzoate (CAS 339103-30-9)
- Dabigatran Impurity 59 (CAS CATO-C4X-108959)
- Cholesterol Impurity 29 (CAS 881024-99-3)
- Hesperidin Impurity 9 (CAS CATO-C4X-33279)
- Trans-2-hydroxycyclohexanecarboxamide (CAS 24947-95-3)
- 4-Hydroxy-N1,N1,N3-trimethylisophthalamide (CAS 1243286-90-9)
- 3-(Ethylsulfonyl)cyclohexan-1-amine (CAS 1340463-40-2)
- Olopatadine Impurity 28 (CAS 55453-89-9)
- 8-Isopropyl-1,3-diazaspiro[4.5]decane-2,4-dione (CAS 91216-35-2)
- N-(3-(Trifluoromethoxy)phenyl)hydrazinecarbothioamide (CAS 1152549-22-8)
- Peptide 438 (CAS CATO-CPTD788438)
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