Riociguat EP Impurity D CAS 625115-54-0
| CAS No. | 625115-54-0 |
| Molecular Formula | C22H23FN8O2 |
| Molecular Weight | 450.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Riociguat EP Impurity D (CAS 625115-54-0, C22H23FN8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Riociguat EP Impurity D (C22H23FN8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Riociguat EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H23FN8O2 |
| Molecular Weight | 450.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat Impurity N2 （E-isomer） (CAS 370879-49-5)
- Riociguat Impurity N40 (CAS 428854-23-3)
- Riociguat Impurity 33 (CAS CATO-C4X-174933)
- Riociguat Impurity 4 (CAS CATO-C4X-17494)
- Riociguat Impurity 32 (CAS CATO-C4X-174932)
- Riociguat EP Impurity C (CAS CATO-C4X-174914)
- Riociguat Impurity 19 (CAS CATO-C4X-174919)
- Riociguat Impurity 37 (CAS CATO-C4X-174937)
Recommended Standards
- N-(Methylsulfonyl)-N-(4-((3-nitroacridin-9-yl)amino)phenyl)acetamide (CAS 61068-04-0)
- Fluocinolone Acetonide Impurity 16 (CAS CATO-C4X-238116)
- 5-Acetyl-6-methyl-2-((4-nitrobenzyl)thio)-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carbonitrile (CAS 299200-86-5)
- Fluocinolone Acetonide EP Impurity D (CAS 13242-30-3)
- Cefepime EP Impurity A (CAS 149261-27-8)
- Prasugrel Impurity 37 (CAS 866761-71-9)
- Amitriptyline EP Impurity E (CAS 26360-49-6（free base）)
- Ozagrel Impurity 43 (CAS CATO-C4X-197143)
- Iguratimod Impurity 18 (CAS CATO-C4X-182618)
- 2-(2-(6-Fluoroimidazo[1,2-a]pyridin-2-yl)ethyl)isoindoline-1,3-dione (CAS 1417636-77-1)
- 2-(3-Cyanophenyl)-2-trifluoromethylacetophenone (CAS 898784-51-5)
- 4-(Methylthio)benzenepropanamine (CAS 83987-53-5)
- N-(4-butyrylphenyl)acetamide (CAS 13211-00-2)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
Why CATO?
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