Riociguat impurity 28 CAS CATO-C4X-174928
| CAS No. | CATO-C4X-174928 |
| Molecular Formula | C21H20FN9O3 |
| Molecular Weight | 465.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 465.44 g/mol gives Riociguat impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Riociguat impurity 28 (CAS CATO-C4X-174928) is a certified pharmaceutical impurity reference standard with the molecular formula C21H20FN9O3 and a molecular weight of 465.44 g/mol.
Based on its molecular formula C21H20FN9O3, Riociguat impurity 28 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 465.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Riociguat impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20FN9O3 |
| Molecular Weight | 465.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 9 |
Related Riociguat Standards
- Riociguat Impurity 25 (CAS CATO-C4X-174925)
- Riociguat EP Impurity D (CAS 625115-54-0)
- Riociguat Impurity 30 (CAS 2518331-19-4)
- Riociguat Impurity N2 （E-isomer） (CAS 370879-49-5)
- Riociguat Impurity N40 (CAS 428854-23-3)
- Riociguat Impurity 33 (CAS CATO-C4X-174933)
- Riociguat Impurity 4 (CAS CATO-C4X-17494)
- Riociguat Impurity 32 (CAS CATO-C4X-174932)
Recommended Standards
- Xen 103 (CAS 840489-44-3)
- (2S,3R,4R,5R,6R)-6-(acetoxymethyl)-3-((4-methoxybenzylidene)amino)tetrahydro-2H-pyran-2,4,5-triyl triacetate (CAS 34948-61-3)
- N-(N-(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)sulfamoyl)-2-hydroxybenzamide (CAS 873556-29-7)
- Acetic acid 4,5-diacetoxy-6-acetoxymethyl-3-[(4-methoxy-benzylidene)-amino]-tetrahydro-pyran-2-yl ester (CAS 7597-81-1)
- Brexpiprazole Impurity 79 (CAS CATO-C4X-113179)
- Suvorexant Impurity 10 (CAS 1276666-15-9（free base）)
- Posaconazole Impurity 47 (CAS 1388148-29-5)
- Timolol EP Impurity F (CAS 30165-96-9)
- 3,4-Di-O-acetyl-L-arabinal (CAS 3945-18-4)
- N,N-Dimethyl-4′-nitro[1,1′-biphenyl]-4-amine (CAS 2143-87-5)
- 4-Chloro-3-methoxythiophene-2-carboxylic acid (CAS 1508708-17-5)
- 2,2′-Dimethoxy-4,4′-dinitro-1,1′-biphenyl (CAS 2499-70-9)
- 2,5-Dimethyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carboxylic acid (CAS 421565-56-2)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
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