Bumetanide Impurity 8 CAS 25317-76-4
| CAS No. | 25317-76-4 |
| Molecular Formula | C7H7ClN2O4S |
| Molecular Weight | 250.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C7H7ClN2O4S, Bumetanide Impurity 8 contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 250.66 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Bumetanide Impurity 8 (CAS 25317-76-4, C7H7ClN2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bumetanide Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN2O4S |
| Molecular Weight | 250.66 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 20 (CAS CATO-C4X-198620)
- Bumetanide Impurity 117 (CAS 74917-54-7)
- Bumetanide Impurity 14 (CAS 118-97-8)
- Bumetanide Impurity 54 (CAS CATO-C4X-198654)
- Bumetanide Impurity 95 (CAS 688318-18-5)
- Bumetanide Impurity 69 (CAS CATO-C4X-198669)
- Bumetanide Impurity 94 (CAS 202209-14-1)
- Bumetanide Impurity 29 (CAS 32642-56-1)
Recommended Standards
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- 3-((4-Fluorophenyl)sulfonyl)propanoyl chloride (CAS 1017172-18-7)
- Esmolol Impurity 46 (CAS 112805-66-0)
- Linagliptin impurity 149 (CAS CATO-C4X-1101149)
- Ertugliflozin impurity 33 (CAS 2242891-20-7)
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- Leu-Enkephalin (CAS 58822-25-6)
- Calcium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate (CAS 47526-32-7)
- 94838-55-8 Carbamic acid,N-[(4-aminophenyl)methyl]-, 1,1-dimethylethyl ester VZ27935 (CAS 94838-55-8)
- 5-Methoxy-4H-chromen-4-one (CAS 59887-87-5)
- Methyl 2-formyl-6-(trifluoromethyl)nicotinate (CAS 1707682-79-8)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
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