Salicylic Acid Impurity 27 CAS 51904-91-7
| CAS No. | 51904-91-7 |
| Molecular Formula | C8H7ClO5S |
| Molecular Weight | 250.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Salicylic Acid Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Salicylic Acid Impurity 27 (CAS 51904-91-7), a pharmacopoeial impurity reference standard (molecular formula C8H7ClO5S, MW 250.66 g/mol) used for the identification and quantification of trace impurities in APIs.
Salicylic Acid Impurity 27 (C8H7ClO5S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO5S |
| Molecular Weight | 250.66 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Salicylic Standards
- Salicylic Acid Impurity 1 (CAS 89469-32-9)
- Salicylic Acid Impurity 26 (CAS 83957-15-7)
- Salicylic Acid Impurity 21 (CAS CATO-C4X-190221)
- Salicylic acid Impurity 28 (CAS 32499-37-9)
- Salicylic acid impurity 33 (CAS CATO-C4X-190233)
- Salicylic Acid Impurity 23 (CAS CATO-C4X-190223)
- Salicylic Acid Impurity 34 (CAS CATO-C4X-190234)
- Salicylic acid Impurity 13 (CAS CATO-C4X-190213)
Recommended Standards
- Bumetanide Impurity 8 (CAS 25317-76-4)
- Furosemide EP Impurity C (CAS 3086-91-7)
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- Indapamide Impurity 11 (CAS 1856658-28-0)
- Carglumic Acid impurity 7 (CAS 219844-08-3)
- Cloxacillin Impurity 42 (CAS CATO-C4X-232142)
- Cyanocobalamin Impurity 32 (CAS 106217-80-5)
- 6-Isopropoxynaphthalene-2-sulfonyl chloride (CAS 1381947-83-6)
- 2-oxabicyclo[2.2.1]heptan-5-ylmethyl 4-methylbenzenesulfonate (CAS 2817612-96-5)
- 2-[4-(3,4-dichlorophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl]acetic acid (CAS 1152513-85-3)
- 3-(2-Methoxyphenyl)-4-((2,4,5-trimethoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478256-72-3)
- Ethyl 8-bromo-6-chloroimidazo[1,2-a]pyridine-2-carboxylate (CAS 951884-22-3)
- Bakkenolide B; Fukinolide (CAS 18455-98-6)
- Semaglutide impurity 81 (CAS CATO-C4X-222681)
Why CATO?
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