N3-[5-phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-2-chloronicotinamide CAS 256414-68-3
| CAS No. | 256414-68-3 |
| Molecular Formula | C16H9ClF3N3OS |
| Molecular Weight | 383.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N3-[5-phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-2-chloronicotinamide.
N3-[5-phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-2-chloronicotinamide (CAS 256414-68-3) is a high-purity analytical reference standard with the molecular formula C16H9ClF3N3OS and a molecular weight of 383.78 g/mol.
N3-[5-phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-2-chloronicotinamide (C16H9ClF3N3OS) contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N3-[5-phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]-2-chloronicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H9ClF3N3OS |
| Molecular Weight | 383.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Recommended Standards
- N-(5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl)-2-(trifluoromethyl)benzamide (CAS 391863-61-9)
- Lenvatinib Impurity 41 (CAS CATO-C4X-114041)
- 7-(1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)ethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (CAS 303151-82-8)
- 2,3,4-Tribromo-6-(trifluoromethyl)pyridine (CAS 1214383-04-6)
- 7-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid (CAS 1086380-48-4)
- 3-Chloro-2-methyl-N-(4-(2-(3-oxomorpholino)ethyl)thiazol-2-yl)benzenesulfonamide (CAS 376641-49-5)
- N-Methyl-5,6,7,8-tetrahydroquinoline-8-carbothioamide (CAS 62000-33-3)
- 4-(Chloromethyl)-5-(difluoromethyl)-6-iodonicotinic acid (CAS 1807014-59-0)
- 4-(Trifluoromethoxy)benzyl bromide (CAS 50824-05-0)
- 4-Amino-5-chloro-2-ethoxybenzoic Acid D5 (CAS 1346600-23-4)
- 3-Bromo-2-hydroxy-5-methylbenzoic acid (CAS 17746-75-7)
- tert-Butyl (S)-3,3-difluoro-4-(methylamino)piperidine-1-carboxylate (CAS 2820191-00-0)
- Methyl (S)-3-fluoro-4-(pyrrolidin-2-yl)benzoate (CAS 1213931-66-8)
- Angiotensin III Antipeptide (CAS 133605-55-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com