Itraconazole Impurity 66 CAS 2570971-61-6
| CAS No. | 2570971-61-6 |
| Molecular Formula | 2*C33H36Cl2N8O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Itraconazole Impurity 66 (CAS 2570971-61-6, C33H36Cl2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Itraconazole Impurity 66 (C33H36Cl2N8O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Itraconazole Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C33H36Cl2N8O4 |
| Molecular Weight | 679.60 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Atogepant Impurity 39 (CAS CATO-C4X-328539)
- Vilazodone impurity 17 (CAS CATO-C4X-135517)
- Erdafitinib Impurity 4 (CAS 2731009-66-6)
- Rimegepant Impurity 137 (CAS 1373116-08-5)
- 4-((4-Methylcyclohexyl)amino)cyclohexan-1-ol (CAS 1152964-08-3)
- 4-Iodopyridazine hydrochloride (CAS 2306265-17-6)
- (5-Benzenesulfonyl-2-phenyl-3H-imidazol-4-ylsulfanyl)-acetic acid (CAS 1171935-29-7)
- (1S,2R)-rel-2-(3-Ethoxy-4-fluorophenyl)cyclopropan-1-amine hydrochloride (CAS 2055841-10-4)
- 9-(propan-2-yl)-3,9-diazabicyclo[4.2.1]nonane (CAS 1208776-86-6)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
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