Paliperidone Impurity 52 CAS 2640158-02-5
| CAS No. | 2640158-02-5 |
| Molecular Formula | C23H27F2N3O3 |
| Molecular Weight | 431.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Paliperidone Impurity 52 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Paliperidone Impurity 52 (CAS 2640158-02-5), a pharmacopoeial impurity reference standard (molecular formula C23H27F2N3O3, MW 431.48 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Paliperidone Impurity 52 (C23H27F2N3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Paliperidone Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27F2N3O3 |
| Molecular Weight | 431.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Paliperidone Standards
- Paliperidone-d4 (CAS 1020719-55-4)
- Paliperidone Impurity 75 (CAS CATO-C4X-172475)
- Paliperidone Impurity 149 (CAS CATO-C4X-1724149)
- Paliperidone Impurity 114 (CAS CATO-C4X-1724114)
- Paliperidone Impurity 5 (CAS 152542-03-5)
- Paliperidone Impurity 117 (CAS CATO-C4X-1724117)
- Paliperidone Impurity 118 (CAS CATO-C4X-1724118)
- Paliperidone impurity 133 (CAS CATO-C4X-1724133)
Recommended Standards
- Nicardipine Impurity 13 (CAS CATO-C4X-171013)
- Ammoxetine Impurity 8 (CAS CATO-C4X-33578)
- Posaconazole Impurity 138 (CAS CATO-C4X-1208138)
- N-Butyl Nortadalafil (CAS 171596-31-9)
- Acotiamide Impurity 34 (CAS CATO-C4X-111434)
- Amisulpride Impurity 29 (CAS 148516-69-2)
- N-Nitroso Tiotropium impurity 52 (CAS CATO-C4X-176452)
- Pyridoxine EP Impurity A hydrochloride (CAS 1006-21-9)
- Rufinamide D2 Metabolite (CAS 1346597-78-1)
- Dibenzyl<I>N</I>,<I>N</I>-dimethylphosphoramidite (CAS 164654-49-3)
- 2-((Cyclopropyl(furan-2-yl)methyl)amino)ethanol (CAS 1306592-62-0)
- Methyl 3-amino-2-(5-methoxy-1H-indol-3-yl)propanoate hydrochloride (CAS 72318-55-9)
- 2-(benzylamino)-N-methylacetamide hydrochloride (CAS 937396-50-4)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
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