Paliperidone Impurity 149 CAS CATO-C4X-1724149
| CAS No. | CATO-C4X-1724149 |
| Molecular Formula | C24H25F3N2O2 |
| Molecular Weight | 430.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Paliperidone Impurity 149 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Paliperidone Impurity 149 (CAS CATO-C4X-1724149) is a certified pharmaceutical impurity reference standard with the molecular formula C24H25F3N2O2 and a molecular weight of 430.46 g/mol.
The molecular framework of Paliperidone Impurity 149 (C24H25F3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25F3N2O2 |
| Molecular Weight | 430.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Paliperidone Standards
- Paliperidone Impurity 75 (CAS CATO-C4X-172475)
- Paliperidone-d4 (CAS 1020719-55-4)
- Paliperidone Impurity 114 (CAS CATO-C4X-1724114)
- Paliperidone Impurity 5 (CAS 152542-03-5)
- Paliperidone Impurity 52 (CAS 2640158-02-5)
- Paliperidone Impurity 117 (CAS CATO-C4X-1724117)
- Paliperidone Impurity 118 (CAS CATO-C4X-1724118)
- Paliperidone impurity 133 (CAS CATO-C4X-1724133)
Recommended Standards
- Azilsartan Impurity 7 (CAS 1397836-49-5)
- Upadacitinib Impurity 127 (CAS CATO-C4X-2405127)
- Azilsartan Impurity 32 (CAS CATO-C4X-109632)
- Finerenone Impurity 37 (CAS 2924224-42-8)
- Butylphthalide Impurity 31 (CAS 96610-56-9)
- Revefenacin Impurity 12 (CAS CATO-C4X-203112)
- Finerenone Impurity 139 (CAS CATO-C4X-2880139)
- Methyl N-(3-hydroxyphenyl)-carbamate (CAS 13683-89-1)
- 6,8-Difluoro-3-isopropyl-2-methylquinolin-4-ol (CAS 1405739-12-9)
- Palbociclib Impurity 159 (CAS 2204368-66-9)
- 2-[2-(Pentyloxy)ethyl]piperidine hydrochloride (CAS 1220028-75-0)
- 5-Bromo-N-(pyridin-2-ylmethyl)nicotinamide (CAS 444076-35-1)
- (3R)-3-methoxyazepane (CAS 2165412-44-0)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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