Canertinib CAS 267243-28-7
| CAS No. | 267243-28-7 |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Canertinib (CAS 267243-28-7), molecular formula C24H25ClFN5O3 and molecular weight 485.94 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Canertinib is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 485.94 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Canertinib Standards
Recommended Standards
- Afatinib (CAS 850140-72-6)
- Afatinib (CAS 439081-18-2)
- (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (CAS 439081-17-1)
- Afatinib impurity 12 (CAS 1680184-59-1)
- ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate (CAS 55400-73-2)
- (S)-1-(2,4-Difluorophenyl)ethanamine Hydrochloride (CAS 844647-37-6)
- tert-Butyl ((1-((5-bromothiophen-2-yl)sulfonyl)piperidin-2-yl)methyl)carbamate (CAS 1261235-54-4)
- 2-(2-(Difluoromethoxy)-3-methoxybenzoyl)pyridine (CAS 1261799-26-1)
- 3-Isocyanato-2-methylfuran (CAS 921938-65-0)
- 1-((3,4-Dichlorobenzyl)(methyl)amino)-3-methoxypropan-2-ol (CAS 1333669-44-5)
- 2-Fluorocycloheptan-1-one (CAS 1755-11-9)
- 2-[4-(1H-Imidazol-1-yl)phenyl]quinoline (CAS 861210-39-1)
- 5-Cyclopropoxy-4-ethylpyridin-3-amine (CAS 1243287-76-4)
- Hexapeptide-9 (CAS 1228371-11-6)
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