Afatinib impurity 12 CAS 1680184-59-1
| CAS No. | 1680184-59-1 |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Afatinib impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Afatinib impurity 12 (CAS 1680184-59-1) is a certified pharmaceutical impurity reference standard with the molecular formula C24H25ClFN5O3 and a molecular weight of 485.94 g/mol.
Based on its molecular formula C24H25ClFN5O3, Afatinib impurity 12 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 485.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
Recommended Standards
- Canertinib (CAS 267243-28-7)
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (CAS 439081-17-1)
- CMC2026 Impurity 1 (CAS CATO-C4X-22661)
- Argatroban Impurity 36 (CAS CATO-C4X-100736)
- Tadalafil Impurity 78 (CAS CATO-C4X-108778)
- Pitavastatin Impurity 96 (CAS 121660-11-5)
- 2-Chloro-5-(pyridin-2-yl)benzoic acid (CAS 1143024-51-4)
- 1-tert-Butyl 2-methyl indoline-1,2-dicarboxylate (CAS 186704-03-0)
- 3-(Ethoxymethyl)-4-methoxybenzaldehyde (CAS 832737-85-6)
- 6-(2-Aminoethyl)-4-chloropyridin-3-ol (CAS 1393539-05-3)
- 4-((2-Fluorobenzyl)oxy)-N'-hydroxybenzimidamide (CAS 261965-35-9)
- 6-(Trifluoromethoxy)chromane (CAS 1512520-26-1)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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