Avatrombopag Impurity 2 CAS 2681355-40-6
| CAS No. | 2681355-40-6 |
| Molecular Formula | C29H34Cl2N6O4S2 |
| Molecular Weight | 665.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avatrombopag Impurity 2.
Avatrombopag Impurity 2 (CAS 2681355-40-6) is a certified pharmaceutical impurity reference standard with the molecular formula C29H34Cl2N6O4S2 and a molecular weight of 665.65 g/mol.
The molecular framework of Avatrombopag Impurity 2 (C29H34Cl2N6O4S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Avatrombopag Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H34Cl2N6O4S2 |
| Molecular Weight | 665.65 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 128 (CAS CATO-C4X-2234128)
- Avatrombopag Impurity 108 (CAS 2489330-90-5)
- Avatrombopag Impurity 45 (CAS CATO-C4X-223445)
- Avatrombopag Impurity 120 (CAS CATO-C4X-2234120)
- Avatrombopag Impurity 122 (CAS CATO-C4X-2234122)
- Avatrombopag Impurity 29 (CAS 570403-14-4)
- Avatrombopag Impurity 33 (CAS CATO-C4X-223433)
- Avatrombopag Impurity 121 (CAS CATO-C4X-2234121)
Recommended Standards
- Chloro[[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](N,N-dimethylbenzylamine)palladium(II)] (CAS 930796-10-4)
- Aripiprazole Impurity 58 (CAS 1424857-63-5)
- Ac-Tyr-Val-Ala-Asp-AMC (CAS 149231-65-2)
- N,N'-(5,10,15,17-Tetraoxo-10,15,16,17-tetrahydro-5H-dinaphtho[2,3-a:2',3'-i]carbazole-4,11-diyl)dibenzamide (CAS 2379-78-4)
- Remdesivir Impurity 32 (CAS CATO-C4X-210032)
- Ibuprofen EP Impurity K (CAS 43153-07-7)
- Imatinib Impurity 74 (CAS CATO-C4X-106874)
- 6-Chloro-3-methoxybenzo[d]isoxazole (CAS 1072903-41-3)
- n-(3-Fluoro-4-methylbenzyl)-2-methoxyethan-1-amine (CAS 1247205-56-6)
- H-Gly-Gly-Lys-Ala-Ala-OH (H-3450.0050) (CAS 68171-99-3)
- (E)-Hexadec-2-enoic acid (CAS 929-79-3)
- (11bS)-2,6-bis[4-(1,1-dimethylethyl)-2,6-bis(1-methylethyl)phenyl]-4-hydroxy-4-oxide-4λ5-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin (CAS 1219498-54-0)
- Methyl 3-azabicyclo[3.2.0]heptane-6-carboxylate (CAS 1784651-28-0)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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