Thiamphenicol Impurity 4 CAS 27348-52-3
| CAS No. | 27348-52-3 |
| Molecular Formula | C12H15Cl2NO5S |
| Molecular Weight | 356.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Thiamphenicol Impurity 4 (C12H15Cl2NO5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 356.22 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Thiamphenicol Impurity 4 (CAS 27348-52-3, C12H15Cl2NO5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H15Cl2NO5S |
| Molecular Weight | 356.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Thiamphenicol Standards
- Thiamphenicol (CAS 847-25-6)
- Thiamphenicol Impurity 2 (CAS 19934-71-5)
- Thiamphenicol Impurity 6 (CAS 21079-44-7)
- Thiamphenicol (CAS 15318-45-3)
- Thiamphenicol-Methyl-D3 (CAS CATO-CCAD300798)
- ent-Thiamphenicol-d3 (CAS 1217723-41-5)
- Thiamphenicol Impurity 10 (CAS 126813-11-4)
- Thiamphenicol Impurity 9 (CAS 126429-09-2)
Recommended Standards
- WP1066 (CAS 857064-38-1)
- Dotinurad Impurity 110 (CAS 888730-54-9)
- Dotinurad Impurity 174 (CAS CATO-C4X-2494174)
- Ethyl 4,4,4-trifluoro-3-hydroxy-2-((3-(trifluoromethyl)phenyl)diazenyl)but-2-enoate (CAS 866130-98-5)
- Acotiamide Impurity 8 Maleate (CAS 185105-17-3)
- Toceranib Impurity 4 (CAS CATO-C4X-25854)
- Finerenone Impurity 207 (CAS CATO-C4X-2880207)
- 1-{3-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}-3,3-dimethylazetidin-2-one (CAS 861206-54-4)
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- 1-Allyl-3-methyl-1H-pyrazol-5(4H)-one (CAS 58011-99-7)
- N-(2,5-dimethoxybenzyl)-1-(4-methoxyphenyl)methanamine hydrobromide (CAS 1609407-14-8)
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- 2-(4-Cyclobutylfuran-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096330-69-5)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
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