Furosemide EP Impurity B CAS 2736-23-4
| CAS No. | 2736-23-4 |
| Molecular Formula | C7H5Cl2NO4S |
| Molecular Weight | 270.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Furosemide EP Impurity B (C7H5Cl2NO4S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 270.09 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Furosemide EP Impurity B (CAS 2736-23-4, C7H5Cl2NO4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5Cl2NO4S |
| Molecular Weight | 270.09 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 17 (CAS CATO-C4X-140217)
- Furosemide Impurity N5 (CAS 62971-57-7)
- Furosemide Impurity 19 (CAS CATO-C4X-140219)
- Furosemide Impurity 27 (CAS 2760-11-4)
- Furosemide Impurity 8 (CAS 41332-59-6)
- Furosemide Impurity 51 (CAS CATO-C4X-140251)
- Furosemide Impurity 64 (CAS 116436-17-0)
- Furosemide Impurity 44 (CAS CATO-C4X-140244)
Recommended Standards
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