Furosemide Impurity 8 CAS 41332-59-6
| CAS No. | 41332-59-6 |
| Molecular Formula | C7H4Cl2O5S |
| Molecular Weight | 271.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Furosemide Impurity 8.
Furosemide Impurity 8 (CAS 41332-59-6) is a certified pharmaceutical impurity reference standard with the molecular formula C7H4Cl2O5S and a molecular weight of 271.07 g/mol.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Furosemide Impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 271.07 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Furosemide Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4Cl2O5S |
| Molecular Weight | 271.07 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 19 (CAS CATO-C4X-140219)
- Furosemide Impurity 17 (CAS CATO-C4X-140217)
- Furosemide EP Impurity B (CAS 2736-23-4)
- Furosemide Impurity N5 (CAS 62971-57-7)
- Furosemide Impurity 27 (CAS 2760-11-4)
- Furosemide Impurity 51 (CAS CATO-C4X-140251)
- Furosemide Impurity 64 (CAS 116436-17-0)
- Furosemide Impurity 44 (CAS CATO-C4X-140244)
Recommended Standards
- methyl 7-bromo-5-methyl-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylate (CAS 2091031-85-3)
- Methyl 4-bromo-5-(difluoromethyl)thiophene-2-carboxylate (CAS 1207557-47-8)
- Methyl 5-amino-6-bromoimidazo[1,5-a]pyrazine-1-carboxylate (CAS 2803475-98-9)
- (4-bromo-2-fluorophenyl)methanesulfonyl fluoride (CAS 1240528-68-0)
- Bortezomib Impurity 46 (CAS CATO-C4X-107246)
- Cefditoren Pivoxil Impurity 5 (CAS 878002-86-9)
- Tacrolimus EP Impurity B (CAS CATO-C4X-130045)
- Riboflavin Impurity 13 (CAS 4250-90-2)
- methyl 1-[(2-nitrophenoxy)methyl]-1H-pyrazole-3-carboxylate (CAS 1003988-83-7)
- 2-(3-(((1-Isopropyl-3-methyl-1H-pyrazol-4-yl)methyl)amino)-1H-pyrazol-1-yl)ethan-1-ol hydrochloride (CAS 1856022-16-6)
- 1,3-Benzenedicarboxylic acid, polymer with 1,4-benzenedicarboxylic acid and 1,6-hexanediol (CAS 26266-80-8)
- (1-(2-(Cyclopentanecarboxamido)acetyl)pyrrolidin-2-yl)boronic acid (CAS 915283-71-5)
- (Z)-2,2,2-trifluoro-1-(1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)ethan-1-one O-(4-fluorobenzoyl) oxime (CAS 860788-00-7)
- Glucagon receptor antagonist I (CAS 438618-32-7)
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