Empagliflozin impurity 274 CAS 2744280-73-5
| CAS No. | 2744280-73-5 |
| Molecular Formula | C18H18BrClO |
| Molecular Weight | 365.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Empagliflozin impurity 274 (C18H18BrClO) contains a steroid core, a hydroxyl group, an ether linkage, chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Empagliflozin impurity 274 (CAS 2744280-73-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18BrClO and a molecular weight of 365.69 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Empagliflozin impurity 274 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H18BrClO |
| Molecular Weight | 365.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl/Br-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 293 (CAS 1185339-44-9)
- Empagliflozin Impurity 105 (CAS 915095-90-8)
- Empagliflozin Impurity 167 (CAS CATO-C4X-1065167)
- Empagliflozin impurity 177 (CAS CATO-C4X-1065177)
- Empagliflozin impurity 178 (CAS CATO-C4X-1065178)
- Empagliflozin Impurity 25 (CAS 915095-89-5)
- Empagliflozin Impurity 66 (CAS 2744280-76-8)
- Empagliflozin Impurity 145 (CAS CATO-C4X-1065145)
Recommended Standards
- 4-[7-(Chlorodifluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidin-2-yl]-1-methyl-5-(trifluoromethyl)-1H-pyrazole (CAS 956165-30-3)
- 1-((4-Bromophenyl)(4-chlorophenyl)methyl)piperazine (CAS 512164-58-8)
- N-(4-Chlorophenyl)-2,2-difluoro-2-[3-(trifluoromethyl)phenoxy]acetamide (CAS 338792-02-2)
- 5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-N-[(1E)-(hydroxyamino)methylidene]-4,5-dihydro-1,2-oxazole-3-carboxamide (CAS 338410-26-7)
- Piribedil Impurity N5 (CAS 1022849-90-6)
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- Argatroban Impurity 92 (CAS CATO-C4X-100792)
- N-(4-Aminophenyl)-3,5-dichlorobenzamide (CAS 926223-09-8)
- 4-Piperidineethanol Hydrochloride (CAS 90747-17-4)
- (3,4-Dimethylphenyl)(2-iodophenyl)methanone (CAS 951892-48-1)
- Ethyl 3-(6-aminopyridin-3-yl)propanoate (CAS 666721-07-9)
- 5-Bromo-2-oxo-N-phenyl-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 400083-36-5)
- 2-((((8beta)-6-Propylergolin-8-yl)methyl)thio)acetic Acid (CAS 478815-25-7)
- (Des-His1,Glu?)-Glucagon (1-29) amide (human, rat, porcine) (CAS 110084-95-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com