Empagliflozin Impurity 145 CAS CATO-C4X-1065145
| CAS No. | CATO-C4X-1065145 |
| Molecular Formula | C20H25ClO2Si |
| Molecular Weight | 360.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Empagliflozin Impurity 145 (CAS CATO-C4X-1065145), a pharmacopoeial impurity reference standard (molecular formula C20H25ClO2Si, MW 360.95 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Empagliflozin Impurity 145 (C20H25ClO2Si) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25ClO2Si |
| Molecular Weight | 360.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 214 (CAS 2819995-58-7)
- Empagliflozin Impurity 104 (CAS 76049-49-5)
- Empagliflozin Impurity 132 (CAS 2452301-23-2)
- Empagliflozin impurity 247 (CAS CATO-C4X-1065247)
- Empagliflozin impurity 248 (CAS 143128-40-9)
- Empagliflozin impurity 252 (CAS CATO-C4X-1065252)
- Empagliflozin impurity 22 (CAS CATO-C4X-1065322)
- Empagliflozin Impurity 45 (CAS CATO-C4X-106545)
Recommended Standards
- N-(2,6-dibromo-4-(trifluoromethyl)phenyl)acetamide (CAS 544716-06-5)
- SIFSIX-3-Ni (CAS 1801992-25-5)
- 18-Chloro-18-oxooctadecan-7-yl acetate (CAS 102376-29-4)
- Diaqua[μ-[2,5-di(hydroxy-κO)-1,4-benzenedicarboxylato(4-)-κO1:κO4]]dizinc (CAS 1033723-90-8)
- Trazodone Impurity 107 (CAS CATO-C4X-1772107)
- Indigo Carmine Impurity 2 (CAS CATO-C4X-32602)
- Repaglinide Impurity 15 (CAS 88709-17-5)
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- Ethyl 5-hydroxy-2-(methylthio)-7-oxo-8-propyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate (CAS 76360-85-5)
- Ethyl 6-oxo-6-[2-(piperidinomethyl)phenyl]hexanoate (CAS 898773-95-0)
- 1-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-2-(5-fluoro-6-methylpyridin-2-yl)ethane-1,2-dione (CAS 943442-82-8)
- (Pyridin-2-ylmethylene)bis(4,1-phenylene) bis(hydrogen sulfate) (CAS 10040-34-3)
- 5-Methyl-1,3,2-dioxathiane 2,2-dioxide (CAS 62822-68-8)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com